TY - JOUR
T1 - Ti6Al4V biomimetic scaffolds for bone tissue engineering
T2 - Fabrication, biomechanics and osseointegration
AU - Liu, Jiantao
AU - Wang, Runqing
AU - Gong, Xi
AU - Zhu, Yihan
AU - Shen, Chengyu
AU - Zhu, Zhixian
AU - Li, Yiming
AU - Li, Zhuoyue
AU - Ren, Zhiwei
AU - Chen, Xiaopeng
AU - Bian, Weiguo
AU - Wang, Dezhi
AU - Yang, Xiaobin
AU - Zhang, Yingang
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/10
Y1 - 2023/10
N2 - The design of porous structure that mimic trabecular bone is an effective method for optimizing the elastic modulus and osseointegration properties of titanium alloy implants. However, there is no consensus on which structure is best. In this study, we fabricated 24 different types of Ti6Al4V trabecular bone scaffolds with varying porosity and average pore size using Voronoi algorithm and selective laser melting technology. The biomechanics and osseointegration properties were studied by mechanical tests, computational fluid dynamics, cell and animal experiments. Our results showed that with an increase of porosity and average pore size, the scaffold's yield strength, ultimate strength, elastic modulus and shear stress exhibited an overall decreasing trend while the permeability and nutrient transport improved. Cell experiments showed that reducing the average pore size enhanced the adhesion and proliferation of MC3T3-E1 cells when the porosity was constant. Animal experiments showed that the scaffold with 65% porosity and 550 μm pore size had the most significant new bone formation effect. Based on our research results, we concluded that a porous structure design with 65% porosity and an average pore size of 550 μm, resembling bone trabecular, had the most significant effect on enhancing the comprehensive performance of titanium alloy implants.
AB - The design of porous structure that mimic trabecular bone is an effective method for optimizing the elastic modulus and osseointegration properties of titanium alloy implants. However, there is no consensus on which structure is best. In this study, we fabricated 24 different types of Ti6Al4V trabecular bone scaffolds with varying porosity and average pore size using Voronoi algorithm and selective laser melting technology. The biomechanics and osseointegration properties were studied by mechanical tests, computational fluid dynamics, cell and animal experiments. Our results showed that with an increase of porosity and average pore size, the scaffold's yield strength, ultimate strength, elastic modulus and shear stress exhibited an overall decreasing trend while the permeability and nutrient transport improved. Cell experiments showed that reducing the average pore size enhanced the adhesion and proliferation of MC3T3-E1 cells when the porosity was constant. Animal experiments showed that the scaffold with 65% porosity and 550 μm pore size had the most significant new bone formation effect. Based on our research results, we concluded that a porous structure design with 65% porosity and an average pore size of 550 μm, resembling bone trabecular, had the most significant effect on enhancing the comprehensive performance of titanium alloy implants.
KW - Biomechanics
KW - Osseointegration
KW - Pore size
KW - Porosity
KW - Titanium alloy
KW - Trabecular bone scaffold
UR - https://www.scopus.com/pages/publications/85172378596
U2 - 10.1016/j.matdes.2023.112330
DO - 10.1016/j.matdes.2023.112330
M3 - 文章
AN - SCOPUS:85172378596
SN - 0264-1275
VL - 234
JO - Materials and Design
JF - Materials and Design
M1 - 112330
ER -