Three-dimensional biomimetic reconstruct and two-phase flow analysis of the microtubules of natural bone

The microstructure of bone tissue is investigated and analyzed to guide the design of internal microchannel architectures for scaffold. 3D reconstructions and the associated designs of the microstructure of bone tissue obtained via histologic sections are conducted with MATLAB, Mimics and PROE. Two-phase flow analysis in the bone microtubules is analyzed and the distribution of cell volume concentration is demonstrated. A comparison with the design based on energy conservation law indicates the higher porosity, more identical channel spacing and larger specific surface of the proposed reconstructed bone, but whose uniformity of distribution of cell volume concentration (1.635%-2.131%) is less than the former (1.960%-2.050%) . Thus, the flow field is considered primarily in scaffold design, then the possibly identical channel spacing and large specific area are taken into account to ensure complete material degradation.