Thermo-induced decarboxylative α-C(sp3)-H fluoroalkylation of glycine derivatives with fluorinated peroxy esters

Zi Hang Yuan; Hong Xin; Jing Qi Tao; Ying Jie Ma; Xin Hua Duan; Li Na Guo

doi:10.1039/d2qo00613h

Thermo-induced decarboxylative α-C(sp³)-H fluoroalkylation of glycine derivatives with fluorinated peroxy esters

Zi Hang Yuan
, Hong Xin
, Jing Qi Tao
, Ying Jie Ma
, Xin Hua Duan
, Li Na Guo

School of Chemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A thermo-induced decarboxylative α-C(sp³)-H fluoroalkylation of glycine derivatives with fluorinated peroxy esters was described. This protocol features transition metal free and redox-neutral conditions, broad substrate scope and excellent functional group tolerance, offering a straightforward route to the fluorinated α-amino acid derivatives in good to excellent yields. Additionally, this strategy was also applicable to the non-fluorinated α-amino acids synthesis.

Original language	English
Pages (from-to)	3546-3551
Number of pages	6
Journal	Organic Chemistry Frontiers
Volume	9
Issue number	13
DOIs	https://doi.org/10.1039/d2qo00613h
State	Published - 11 May 2022

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abstract = "A thermo-induced decarboxylative α-C(sp3)-H fluoroalkylation of glycine derivatives with fluorinated peroxy esters was described. This protocol features transition metal free and redox-neutral conditions, broad substrate scope and excellent functional group tolerance, offering a straightforward route to the fluorinated α-amino acid derivatives in good to excellent yields. Additionally, this strategy was also applicable to the non-fluorinated α-amino acids synthesis.",

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AU - Yuan, Zi Hang

AU - Xin, Hong

AU - Tao, Jing Qi

AU - Ma, Ying Jie

AU - Duan, Xin Hua

AU - Guo, Li Na

PY - 2022/5/11

Y1 - 2022/5/11

N2 - A thermo-induced decarboxylative α-C(sp3)-H fluoroalkylation of glycine derivatives with fluorinated peroxy esters was described. This protocol features transition metal free and redox-neutral conditions, broad substrate scope and excellent functional group tolerance, offering a straightforward route to the fluorinated α-amino acid derivatives in good to excellent yields. Additionally, this strategy was also applicable to the non-fluorinated α-amino acids synthesis.

AB - A thermo-induced decarboxylative α-C(sp3)-H fluoroalkylation of glycine derivatives with fluorinated peroxy esters was described. This protocol features transition metal free and redox-neutral conditions, broad substrate scope and excellent functional group tolerance, offering a straightforward route to the fluorinated α-amino acid derivatives in good to excellent yields. Additionally, this strategy was also applicable to the non-fluorinated α-amino acids synthesis.

UR - https://www.scopus.com/pages/publications/85131140310

U2 - 10.1039/d2qo00613h

DO - 10.1039/d2qo00613h

M3 - 文章

AN - SCOPUS:85131140310

SN - 2052-4110

VL - 9

SP - 3546

EP - 3551

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

IS - 13

ER -

Thermo-induced decarboxylative α-C(sp³)-H fluoroalkylation of glycine derivatives with fluorinated peroxy esters

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