Abstract
Objective: In order to investigate the therapeutic effects of portal arterialization for portal hypertension, portal arterialization and complete shunt (PACS) was applied in canine model of portal hypertension, which was made by thread embolization within the portal vein. Methods: A splenectomy, splenic artery and upper portal vein anastomosis, and a complete portal-caval shunt were performed on portal hypertension dogs. The blood pressure and flow of the portal vein including that towards the liver and towards the vena cava were observed. Results: The postoperative hepatic inflow, PVF, increased to 180% of the former while PVP increased to 196%; the caval-inflow PVF increased to 130% of the former while PVP decreased to 45. 5%. Significant difference existed (P < 0.01). The hepatic function changed little after the operation without any statistic difference. Conclusion: PACS can significantly increase the hepatic inflow and decrease the blood pressure of the portal system with a satisfactory dog survival. It may be a worthy attempt in the treatment of portal hypertension and needs more research work.
| Original language | English |
|---|---|
| Pages (from-to) | 569-571 |
| Number of pages | 3 |
| Journal | Journal of Xi'an Jiaotong University (Medical Sciences) |
| Volume | 28 |
| Issue number | 5 |
| State | Published - Oct 2007 |
Keywords
- Dog
- Portal arterialization
- Portal hypertension
- Treatment