The relationship between RhoA subfamily molecules and malignant phenotype of gastric cancer cells

Guoyun Zhang; Feng Bi; Na Liu; Yanglin Pan; Lijun Sun; Taidong Qiao; Daiming Fan

The relationship between RhoA subfamily molecules and malignant phenotype of gastric cancer cells

Guoyun Zhang
, Feng Bi
, Na Liu
, Yanglin Pan
, Lijun Sun
, Taidong Qiao
, Daiming Fan

Air Force Medical University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Objective: To explore the effect of RhoA subfamily members, i.e., RhoA, RhoB and RhoC, on the malignant phenotype of gastric cancer cells. Methods: The vectors of pCEFL-GST/V14RhoA, pCEFL-GST/wt-RhoB and pCEFL-GST/wt-RhoC were transfected into human gastric cancer cell SGC7901 by lipofectamine2000, respectively. Then the malignant biological behaviors of the transfected cells were explored. Results: The enhancement of RhoA activity can promote the proliferation of gastric cancer cell and can reduce the sensitivity of anticancer drugs; Up-regulation of RhoB can restrain the growth rate of gastric cancer cell and can enhance the sensitivity of anticancer drugs. The up-regulation of RhoC did not affect the proliferation and sensitivity of the anticancer drugs, but can promote the migration of gastric cancer cells. Conclusion: RhoA subfamily members can play an important but different role in regulating malignant behaviors of gastric cancer cells.

Original language	English
Pages (from-to)	1021-1024
Number of pages	4
Journal	Chinese Journal of Clinical Oncology
Volume	33
Issue number	18
State	Published - 2006
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

RhoA
RhoB
RhoC gastric cancer

Cite this

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title = "The relationship between RhoA subfamily molecules and malignant phenotype of gastric cancer cells",

abstract = "Objective: To explore the effect of RhoA subfamily members, i.e., RhoA, RhoB and RhoC, on the malignant phenotype of gastric cancer cells. Methods: The vectors of pCEFL-GST/V14RhoA, pCEFL-GST/wt-RhoB and pCEFL-GST/wt-RhoC were transfected into human gastric cancer cell SGC7901 by lipofectamine2000, respectively. Then the malignant biological behaviors of the transfected cells were explored. Results: The enhancement of RhoA activity can promote the proliferation of gastric cancer cell and can reduce the sensitivity of anticancer drugs; Up-regulation of RhoB can restrain the growth rate of gastric cancer cell and can enhance the sensitivity of anticancer drugs. The up-regulation of RhoC did not affect the proliferation and sensitivity of the anticancer drugs, but can promote the migration of gastric cancer cells. Conclusion: RhoA subfamily members can play an important but different role in regulating malignant behaviors of gastric cancer cells.",

keywords = "RhoA, RhoB, RhoC gastric cancer",

author = "Guoyun Zhang and Feng Bi and Na Liu and Yanglin Pan and Lijun Sun and Taidong Qiao and Daiming Fan",

year = "2006",

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volume = "33",

pages = "1021--1024",

journal = "Chinese Journal of Clinical Oncology",

issn = "1000-8179",

publisher = "China Anti-Cancer Association",

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}

TY - JOUR

T1 - The relationship between RhoA subfamily molecules and malignant phenotype of gastric cancer cells

AU - Zhang, Guoyun

AU - Bi, Feng

AU - Liu, Na

AU - Pan, Yanglin

AU - Sun, Lijun

AU - Qiao, Taidong

AU - Fan, Daiming

PY - 2006

Y1 - 2006

N2 - Objective: To explore the effect of RhoA subfamily members, i.e., RhoA, RhoB and RhoC, on the malignant phenotype of gastric cancer cells. Methods: The vectors of pCEFL-GST/V14RhoA, pCEFL-GST/wt-RhoB and pCEFL-GST/wt-RhoC were transfected into human gastric cancer cell SGC7901 by lipofectamine2000, respectively. Then the malignant biological behaviors of the transfected cells were explored. Results: The enhancement of RhoA activity can promote the proliferation of gastric cancer cell and can reduce the sensitivity of anticancer drugs; Up-regulation of RhoB can restrain the growth rate of gastric cancer cell and can enhance the sensitivity of anticancer drugs. The up-regulation of RhoC did not affect the proliferation and sensitivity of the anticancer drugs, but can promote the migration of gastric cancer cells. Conclusion: RhoA subfamily members can play an important but different role in regulating malignant behaviors of gastric cancer cells.

AB - Objective: To explore the effect of RhoA subfamily members, i.e., RhoA, RhoB and RhoC, on the malignant phenotype of gastric cancer cells. Methods: The vectors of pCEFL-GST/V14RhoA, pCEFL-GST/wt-RhoB and pCEFL-GST/wt-RhoC were transfected into human gastric cancer cell SGC7901 by lipofectamine2000, respectively. Then the malignant biological behaviors of the transfected cells were explored. Results: The enhancement of RhoA activity can promote the proliferation of gastric cancer cell and can reduce the sensitivity of anticancer drugs; Up-regulation of RhoB can restrain the growth rate of gastric cancer cell and can enhance the sensitivity of anticancer drugs. The up-regulation of RhoC did not affect the proliferation and sensitivity of the anticancer drugs, but can promote the migration of gastric cancer cells. Conclusion: RhoA subfamily members can play an important but different role in regulating malignant behaviors of gastric cancer cells.

KW - RhoA

KW - RhoB

KW - RhoC gastric cancer

UR - https://www.scopus.com/pages/publications/58149519363

M3 - 文章

AN - SCOPUS:58149519363

SN - 1000-8179

VL - 33

SP - 1021

EP - 1024

JO - Chinese Journal of Clinical Oncology

JF - Chinese Journal of Clinical Oncology

IS - 18

ER -

The relationship between RhoA subfamily molecules and malignant phenotype of gastric cancer cells

Abstract

UN SDGs

Keywords

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