The phenotypic changes of γδ T cells in COVID-19 patients

Lei Lei; Hongbo Qian; Xiaofang Yang; Xingzhe Zhang; Dan Zhang; Tongxin Dai; Rui Guo; Lin Shi; Yanbin Cheng; Baojun Zhang; Xiaobo Zhou; Jinsong Hu; Yaling Guo

doi:10.1111/jcmm.15620

The phenotypic changes of γδ T cells in COVID-19 patients

Lei Lei
, Hongbo Qian
, Xiaofang Yang
, Xingzhe Zhang
, Dan Zhang
, Tongxin Dai
, Rui Guo
, Lin Shi
, Yanbin Cheng
, Baojun Zhang
, Xiaobo Zhou
, Jinsong Hu
, Yaling Guo

Health Science Center

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

A novel pneumonia-associated respiratory syndrome named coronavirus disease-2019 (COVID-19), which was caused by SARS-CoV-2，broke out in Wuhan, China, in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS-CoV-2 infections. The information regarding the immunological characteristics in COVID-19 patients remains limited. Here, we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes on γδ T cell population. In comparison with HD, the γδ T cell percentage decreased, while the activation marker CD25 expression increased in response to SARS-CoV-2 infection. Interestingly, the CD4 expression was upregulated in γδ T cells reflecting the occurrence of a specific effector cell population, which may serve as a biomarker for the assessment of SARS-CoV-2 infection.

Original language	English
Pages (from-to)	11603-11606
Number of pages	4
Journal	Journal of Cellular and Molecular Medicine
Volume	24
Issue number	19
DOIs	https://doi.org/10.1111/jcmm.15620
State	Published - 1 Oct 2020

Keywords

COVID-19
SARS-CoV-2
activation
innate immunity
γδ T cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/jcmm.15620

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title = "The phenotypic changes of γδ T cells in COVID-19 patients",

abstract = "A novel pneumonia-associated respiratory syndrome named coronavirus disease-2019 (COVID-19), which was caused by SARS-CoV-2，broke out in Wuhan, China, in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS-CoV-2 infections. The information regarding the immunological characteristics in COVID-19 patients remains limited. Here, we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes on γδ T cell population. In comparison with HD, the γδ T cell percentage decreased, while the activation marker CD25 expression increased in response to SARS-CoV-2 infection. Interestingly, the CD4 expression was upregulated in γδ T cells reflecting the occurrence of a specific effector cell population, which may serve as a biomarker for the assessment of SARS-CoV-2 infection.",

keywords = "COVID-19, SARS-CoV-2, activation, innate immunity, γδ T cells",

author = "Lei Lei and Hongbo Qian and Xiaofang Yang and Xingzhe Zhang and Dan Zhang and Tongxin Dai and Rui Guo and Lin Shi and Yanbin Cheng and Baojun Zhang and Xiaobo Zhou and Jinsong Hu and Yaling Guo",

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year = "2020",

month = oct,

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doi = "10.1111/jcmm.15620",

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AU - Lei, Lei

AU - Qian, Hongbo

AU - Yang, Xiaofang

AU - Zhang, Xingzhe

AU - Zhang, Dan

AU - Dai, Tongxin

AU - Guo, Rui

AU - Shi, Lin

AU - Cheng, Yanbin

AU - Zhang, Baojun

AU - Zhou, Xiaobo

AU - Hu, Jinsong

AU - Guo, Yaling

PY - 2020/10/1

Y1 - 2020/10/1

N2 - A novel pneumonia-associated respiratory syndrome named coronavirus disease-2019 (COVID-19), which was caused by SARS-CoV-2，broke out in Wuhan, China, in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS-CoV-2 infections. The information regarding the immunological characteristics in COVID-19 patients remains limited. Here, we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes on γδ T cell population. In comparison with HD, the γδ T cell percentage decreased, while the activation marker CD25 expression increased in response to SARS-CoV-2 infection. Interestingly, the CD4 expression was upregulated in γδ T cells reflecting the occurrence of a specific effector cell population, which may serve as a biomarker for the assessment of SARS-CoV-2 infection.

AB - A novel pneumonia-associated respiratory syndrome named coronavirus disease-2019 (COVID-19), which was caused by SARS-CoV-2，broke out in Wuhan, China, in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS-CoV-2 infections. The information regarding the immunological characteristics in COVID-19 patients remains limited. Here, we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes on γδ T cell population. In comparison with HD, the γδ T cell percentage decreased, while the activation marker CD25 expression increased in response to SARS-CoV-2 infection. Interestingly, the CD4 expression was upregulated in γδ T cells reflecting the occurrence of a specific effector cell population, which may serve as a biomarker for the assessment of SARS-CoV-2 infection.

KW - COVID-19

KW - SARS-CoV-2

KW - activation

KW - innate immunity

KW - γδ T cells

UR - https://www.scopus.com/pages/publications/85089965408

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DO - 10.1111/jcmm.15620

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SN - 1582-1838

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SP - 11603

EP - 11606

JO - Journal of Cellular and Molecular Medicine

JF - Journal of Cellular and Molecular Medicine

IS - 19

ER -

The phenotypic changes of γδ T cells in COVID-19 patients

Abstract

Keywords

UN SDGs

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