The international HapMap project

John W. Belmont; Paul Hardenbol; Thomas D. Willis; Fuli Yu; Huanming Yang; Lan Yang Ch'Ang; Wei Huang; Bin Liu; Yan Shen; Paul Kwong Hang Tam; Lap Chee Tsui; Mary Miu Yee Waye; Jeffrey Tze Fei Wong; Changqing Zeng; Qingrun Zhang; Mark S. Chee; Luana M. Galver; Semyon Kruglyak; Sarah S. Murray; Arnold R. Oliphant; Alexandre Montpetit; Fanny Chagnon; Vincent Ferretti; Martin Leboeuf; Michael S. Phillips; Andrei Verner; Shenghui Duan; Denise L. Lind; Raymond D. Miller; John Rice; Nancy L. Saccone; Patricia Taillon-Miller; Ming Xiao; Akihiro Sekine; Koki Sorimachi; Yoichi Tanaka; Tatsuhiko Tsunoda; Eiji Yoshino; David R. Bentley; Sarah Hunt; Don Powell; Houcan Zhang; Ichiro Matsuda; Yoshimitsu Fukushima; Darryl R. Macer; Eiko Suda; Charles Rotimi; Clement A. Adebamowo; Toyin Aniagwu; Patricia A. Marshall; Olayemi Matthew; Chibuzor Nkwodimmah; Charmaine D.M. Royal; Mark F. Leppert; Missy Dixon; Fiona Cunningham; Ardavan Kanani; Gudmundur A. Thorisson; Peter E. Chen; David J. Cutler; Carl S. Kashuk; Peter Donnelly; Jonathan Marchini; Gilean A.T. McVean; Simon R. Myers; Lon R. Cardon; Andrew Morris; Bruce S. Weir; James C. Mullikin; Michael Feolo; Mark J. Daly; Renzong Qiu; Alastair Kent; Georgia M. Dunston; Kazuto Kato; Norio Niikawa; Jessica Watkin; Richard A. Gibbs; Erica Sodergren; George M. Weinstock; Richard K. Wilson; Lucinda L. Fulton; Jane Rogers; Bruce W. Birren; Hua Han; Hongguang Wang; Martin Godbout; John C. Wallenburg; Paul L'Archevêque; Guy Bellemare; Kazuo Todani; Takashi Fujita; Satoshi Tanaka; Arthur L. Holden; Francis S. Collins; Lisa D. Brooks; Jean E. McEwen; Mark S. Guyer; Elke Jordan; Jane L. Peterson; Jack Spiegel; Lawrence M. Sung; Lynn F. Zacharia; Karen Kennedy; Michael G. Dunn; Richard Seabrook; Mark Shillito; Barbara Skene; John G. Stewart; David L. Valle; Ellen Wright Clayton; Lynn B. Jorde; Aravinda Chakravarti; Mildred K. Cho; Troy Duster; Morris W. Foster; Maria Jasperse; Bartha M. Knoppers; Pui Yan Kwok; Julio Licinio; Jeffrey C. Long; Pilar Ossorio; Vivian Ota Wang; Charles N. Rotimi; Patricia Spallone; Sharon F. Terry; Eric S. Lander; Eric H. Lai; Deborah A. Nickerson; Gonçalo R. Abecasis; David Altshuler; Michael Boehnke; Panos Deloukas; Julie A. Douglas; Stacey B. Gabriel; Richard R. Hudson; Thomas J. Hudson; Leonid Kruglyak; Yusuke Nakamura; Robert L. Nussbaum; Stephen F. Schaffner; Stephen T. Sherry; Lincoln D. Stein; Toshihiro Tanaka

doi:10.1038/nature02168

The international HapMap project

John W. Belmont
, Paul Hardenbol
, Thomas D. Willis
, Fuli Yu
, Huanming Yang
, Lan Yang Ch'Ang
, Wei Huang
, Bin Liu
, Yan Shen
, Paul Kwong Hang Tam
, Lap Chee Tsui
, Mary Miu Yee Waye
, Jeffrey Tze Fei Wong
, Changqing Zeng
, Qingrun Zhang
, Mark S. Chee
, Luana M. Galver
, Semyon Kruglyak
, Sarah S. Murray
, Arnold R. Oliphant

Alexandre Montpetit, Fanny Chagnon, Vincent Ferretti, Martin Leboeuf, Michael S. Phillips, Andrei Verner, Shenghui Duan, Denise L. Lind, Raymond D. Miller, John Rice, Nancy L. Saccone, Patricia Taillon-Miller, Ming Xiao, Akihiro Sekine, Koki Sorimachi, Yoichi Tanaka, Tatsuhiko Tsunoda, Eiji Yoshino, David R. Bentley, Sarah Hunt, Don Powell, Houcan Zhang, Ichiro Matsuda, Yoshimitsu Fukushima, Darryl R. Macer, Eiko Suda, Charles Rotimi, Clement A. Adebamowo, Toyin Aniagwu, Patricia A. Marshall, Olayemi Matthew, Chibuzor Nkwodimmah, Charmaine D.M. Royal, Mark F. Leppert, Missy Dixon, Fiona Cunningham, Ardavan Kanani, Gudmundur A. Thorisson, Peter E. Chen, David J. Cutler, Carl S. Kashuk, Peter Donnelly, Jonathan Marchini, Gilean A.T. McVean, Simon R. Myers, Lon R. Cardon, Andrew Morris, Bruce S. Weir, James C. Mullikin, Michael Feolo, Mark J. Daly, Renzong Qiu, Alastair Kent, Georgia M. Dunston, Kazuto Kato, Norio Niikawa, Jessica Watkin, Richard A. Gibbs, Erica Sodergren, George M. Weinstock, Richard K. Wilson, Lucinda L. Fulton, Jane Rogers, Bruce W. Birren, Hua Han, Hongguang Wang, Martin Godbout, John C. Wallenburg, Paul L'Archevêque, Guy Bellemare, Kazuo Todani, Takashi Fujita, Satoshi Tanaka, Arthur L. Holden, Francis S. Collins, Lisa D. Brooks, Jean E. McEwen, Mark S. Guyer, Elke Jordan, Jane L. Peterson, Jack Spiegel, Lawrence M. Sung, Lynn F. Zacharia, Karen Kennedy, Michael G. Dunn, Richard Seabrook, Mark Shillito, Barbara Skene, John G. Stewart, David L. Valle, Ellen Wright Clayton, Lynn B. Jorde, Aravinda Chakravarti, Mildred K. Cho, Troy Duster, Morris W. Foster, Maria Jasperse, Bartha M. Knoppers, Pui Yan Kwok, Julio Licinio, Jeffrey C. Long, Pilar Ossorio, Vivian Ota Wang, Charles N. Rotimi, Patricia Spallone, Sharon F. Terry, Eric S. Lander, Eric H. Lai, Deborah A. Nickerson, Gonçalo R. Abecasis, David Altshuler, Michael Boehnke, Panos Deloukas, Julie A. Douglas, Stacey B. Gabriel, Richard R. Hudson, Thomas J. Hudson, Leonid Kruglyak, Yusuke Nakamura, Robert L. Nussbaum, Stephen F. Schaffner, Stephen T. Sherry, Lincoln D. Stein, Toshihiro Tanaka

Research output: Contribution to journal › Article › peer-review

5310 Scopus citations

Abstract

The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of these patterns across the genome by determining the genotypes of one million or more sequence variants, their frequencies and the degree of association between them, in DNA samples from populations with ancestry from parts of Africa, Asia and Europe. The HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools, and will enhance our ability to choose targets for therapeutic intervention.

Original language	English
Pages (from-to)	789-796
Number of pages	8
Journal	Nature
Volume	426
Issue number	6968
DOIs	https://doi.org/10.1038/nature02168
State	Published - 18 Dec 2003
Externally published	Yes

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10.1038/nature02168

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@article{4736154154754bfe905484d72d99ea48,

title = "The international HapMap project",

abstract = "The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of these patterns across the genome by determining the genotypes of one million or more sequence variants, their frequencies and the degree of association between them, in DNA samples from populations with ancestry from parts of Africa, Asia and Europe. The HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools, and will enhance our ability to choose targets for therapeutic intervention.",

author = "Belmont, \{John W.\} and Paul Hardenbol and Willis, \{Thomas D.\} and Fuli Yu and Huanming Yang and Ch'Ang, \{Lan Yang\} and Wei Huang and Bin Liu and Yan Shen and Tam, \{Paul Kwong Hang\} and Tsui, \{Lap Chee\} and Waye, \{Mary Miu Yee\} and Wong, \{Jeffrey Tze Fei\} and Changqing Zeng and Qingrun Zhang and Chee, \{Mark S.\} and Galver, \{Luana M.\} and Semyon Kruglyak and Murray, \{Sarah S.\} and Oliphant, \{Arnold R.\} and Alexandre Montpetit and Fanny Chagnon and Vincent Ferretti and Martin Leboeuf and Phillips, \{Michael S.\} and Andrei Verner and Shenghui Duan and Lind, \{Denise L.\} and Miller, \{Raymond D.\} and John Rice and Saccone, \{Nancy L.\} and Patricia Taillon-Miller and Ming Xiao and Akihiro Sekine and Koki Sorimachi and Yoichi Tanaka and Tatsuhiko Tsunoda and Eiji Yoshino and Bentley, \{David R.\} and Sarah Hunt and Don Powell and Houcan Zhang and Ichiro Matsuda and Yoshimitsu Fukushima and Macer, \{Darryl R.\} and Eiko Suda and Charles Rotimi and Adebamowo, \{Clement A.\} and Toyin Aniagwu and Marshall, \{Patricia A.\} and Olayemi Matthew and Chibuzor Nkwodimmah and Royal, \{Charmaine D.M.\} and Leppert, \{Mark F.\} and Missy Dixon and Fiona Cunningham and Ardavan Kanani and Thorisson, \{Gudmundur A.\} and Chen, \{Peter E.\} and Cutler, \{David J.\} and Kashuk, \{Carl S.\} and Peter Donnelly and Jonathan Marchini and McVean, \{Gilean A.T.\} and Myers, \{Simon R.\} and Cardon, \{Lon R.\} and Andrew Morris and Weir, \{Bruce S.\} and Mullikin, \{James C.\} and Michael Feolo and Daly, \{Mark J.\} and Renzong Qiu and Alastair Kent and Dunston, \{Georgia M.\} and Kazuto Kato and Norio Niikawa and Jessica Watkin and Gibbs, \{Richard A.\} and Erica Sodergren and Weinstock, \{George M.\} and Wilson, \{Richard K.\} and Fulton, \{Lucinda L.\} and Jane Rogers and Birren, \{Bruce W.\} and Hua Han and Hongguang Wang and Martin Godbout and Wallenburg, \{John C.\} and Paul L'Archev{\^e}que and Guy Bellemare and Kazuo Todani and Takashi Fujita and Satoshi Tanaka and Holden, \{Arthur L.\} and Collins, \{Francis S.\} and Brooks, \{Lisa D.\} and McEwen, \{Jean E.\} and Guyer, \{Mark S.\} and Elke Jordan and Peterson, \{Jane L.\} and Jack Spiegel and Sung, \{Lawrence M.\} and Zacharia, \{Lynn F.\} and Karen Kennedy and Dunn, \{Michael G.\} and Richard Seabrook and Mark Shillito and Barbara Skene and Stewart, \{John G.\} and Valle, \{David L.\} and Clayton, \{Ellen Wright\} and Jorde, \{Lynn B.\} and Aravinda Chakravarti and Cho, \{Mildred K.\} and Troy Duster and Foster, \{Morris W.\} and Maria Jasperse and Knoppers, \{Bartha M.\} and Kwok, \{Pui Yan\} and Julio Licinio and Long, \{Jeffrey C.\} and Pilar Ossorio and Wang, \{Vivian Ota\} and Rotimi, \{Charles N.\} and Patricia Spallone and Terry, \{Sharon F.\} and Lander, \{Eric S.\} and Lai, \{Eric H.\} and Nickerson, \{Deborah A.\} and Abecasis, \{Gon{\c c}alo R.\} and David Altshuler and Michael Boehnke and Panos Deloukas and Douglas, \{Julie A.\} and Gabriel, \{Stacey B.\} and Hudson, \{Richard R.\} and Hudson, \{Thomas J.\} and Leonid Kruglyak and Yusuke Nakamura and Nussbaum, \{Robert L.\} and Schaffner, \{Stephen F.\} and Sherry, \{Stephen T.\} and Stein, \{Lincoln D.\} and Toshihiro Tanaka",

year = "2003",

month = dec,

day = "18",

doi = "10.1038/nature02168",

language = "英语",

volume = "426",

pages = "789--796",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "6968",

}

Belmont, JW, Hardenbol, P, Willis, TD, Yu, F, Yang, H, Ch'Ang, LY, Huang, W, Liu, B, Shen, Y, Tam, PKH, Tsui, LC, Waye, MMY, Wong, JTF, Zeng, C, Zhang, Q, Chee, MS, Galver, LM, Kruglyak, S, Murray, SS, Oliphant, AR, Montpetit, A, Chagnon, F, Ferretti, V, Leboeuf, M, Phillips, MS, Verner, A, Duan, S, Lind, DL, Miller, RD, Rice, J, Saccone, NL, Taillon-Miller, P, Xiao, M, Sekine, A, Sorimachi, K, Tanaka, Y, Tsunoda, T, Yoshino, E, Bentley, DR, Hunt, S, Powell, D, Zhang, H, Matsuda, I, Fukushima, Y, Macer, DR, Suda, E, Rotimi, C, Adebamowo, CA, Aniagwu, T, Marshall, PA, Matthew, O, Nkwodimmah, C, Royal, CDM, Leppert, MF, Dixon, M, Cunningham, F, Kanani, A, Thorisson, GA, Chen, PE, Cutler, DJ, Kashuk, CS, Donnelly, P, Marchini, J, McVean, GAT, Myers, SR, Cardon, LR, Morris, A, Weir, BS, Mullikin, JC, Feolo, M, Daly, MJ, Qiu, R, Kent, A, Dunston, GM, Kato, K, Niikawa, N, Watkin, J, Gibbs, RA, Sodergren, E, Weinstock, GM, Wilson, RK, Fulton, LL, Rogers, J, Birren, BW, Han, H, Wang, H, Godbout, M, Wallenburg, JC, L'Archevêque, P, Bellemare, G, Todani, K, Fujita, T, Tanaka, S, Holden, AL, Collins, FS, Brooks, LD, McEwen, JE, Guyer, MS, Jordan, E, Peterson, JL, Spiegel, J, Sung, LM, Zacharia, LF, Kennedy, K, Dunn, MG, Seabrook, R, Shillito, M, Skene, B, Stewart, JG, Valle, DL, Clayton, EW, Jorde, LB, Chakravarti, A, Cho, MK, Duster, T, Foster, MW, Jasperse, M, Knoppers, BM, Kwok, PY, Licinio, J, Long, JC, Ossorio, P, Wang, VO, Rotimi, CN, Spallone, P, Terry, SF, Lander, ES, Lai, EH, Nickerson, DA, Abecasis, GR, Altshuler, D, Boehnke, M, Deloukas, P, Douglas, JA, Gabriel, SB, Hudson, RR, Hudson, TJ, Kruglyak, L, Nakamura, Y, Nussbaum, RL, Schaffner, SF, Sherry, ST, Stein, LD & Tanaka, T 2003, 'The international HapMap project', Nature, vol. 426, no. 6968, pp. 789-796. https://doi.org/10.1038/nature02168

TY - JOUR

T1 - The international HapMap project

AU - Belmont, John W.

AU - Hardenbol, Paul

AU - Willis, Thomas D.

AU - Yu, Fuli

AU - Yang, Huanming

AU - Ch'Ang, Lan Yang

AU - Huang, Wei

AU - Liu, Bin

AU - Shen, Yan

AU - Tam, Paul Kwong Hang

AU - Tsui, Lap Chee

AU - Waye, Mary Miu Yee

AU - Wong, Jeffrey Tze Fei

AU - Zeng, Changqing

AU - Zhang, Qingrun

AU - Chee, Mark S.

AU - Galver, Luana M.

AU - Kruglyak, Semyon

AU - Murray, Sarah S.

AU - Oliphant, Arnold R.

AU - Montpetit, Alexandre

AU - Chagnon, Fanny

AU - Ferretti, Vincent

AU - Leboeuf, Martin

AU - Phillips, Michael S.

AU - Verner, Andrei

AU - Duan, Shenghui

AU - Lind, Denise L.

AU - Miller, Raymond D.

AU - Rice, John

AU - Saccone, Nancy L.

AU - Taillon-Miller, Patricia

AU - Xiao, Ming

AU - Sekine, Akihiro

AU - Sorimachi, Koki

AU - Tanaka, Yoichi

AU - Tsunoda, Tatsuhiko

AU - Yoshino, Eiji

AU - Bentley, David R.

AU - Hunt, Sarah

AU - Powell, Don

AU - Zhang, Houcan

AU - Matsuda, Ichiro

AU - Fukushima, Yoshimitsu

AU - Macer, Darryl R.

AU - Suda, Eiko

AU - Rotimi, Charles

AU - Adebamowo, Clement A.

AU - Aniagwu, Toyin

AU - Marshall, Patricia A.

AU - Matthew, Olayemi

AU - Nkwodimmah, Chibuzor

AU - Royal, Charmaine D.M.

AU - Leppert, Mark F.

AU - Dixon, Missy

AU - Cunningham, Fiona

AU - Kanani, Ardavan

AU - Thorisson, Gudmundur A.

AU - Chen, Peter E.

AU - Cutler, David J.

AU - Kashuk, Carl S.

AU - Donnelly, Peter

AU - Marchini, Jonathan

AU - McVean, Gilean A.T.

AU - Myers, Simon R.

AU - Cardon, Lon R.

AU - Morris, Andrew

AU - Weir, Bruce S.

AU - Mullikin, James C.

AU - Feolo, Michael

AU - Daly, Mark J.

AU - Qiu, Renzong

AU - Kent, Alastair

AU - Dunston, Georgia M.

AU - Kato, Kazuto

AU - Niikawa, Norio

AU - Watkin, Jessica

AU - Gibbs, Richard A.

AU - Sodergren, Erica

AU - Weinstock, George M.

AU - Wilson, Richard K.

AU - Fulton, Lucinda L.

AU - Rogers, Jane

AU - Birren, Bruce W.

AU - Han, Hua

AU - Wang, Hongguang

AU - Godbout, Martin

AU - Wallenburg, John C.

AU - L'Archevêque, Paul

AU - Bellemare, Guy

AU - Todani, Kazuo

AU - Fujita, Takashi

AU - Tanaka, Satoshi

AU - Holden, Arthur L.

AU - Collins, Francis S.

AU - Brooks, Lisa D.

AU - McEwen, Jean E.

AU - Guyer, Mark S.

AU - Jordan, Elke

AU - Peterson, Jane L.

AU - Spiegel, Jack

AU - Sung, Lawrence M.

AU - Zacharia, Lynn F.

AU - Kennedy, Karen

AU - Dunn, Michael G.

AU - Seabrook, Richard

AU - Shillito, Mark

AU - Skene, Barbara

AU - Stewart, John G.

AU - Valle, David L.

AU - Clayton, Ellen Wright

AU - Jorde, Lynn B.

AU - Chakravarti, Aravinda

AU - Cho, Mildred K.

AU - Duster, Troy

AU - Foster, Morris W.

AU - Jasperse, Maria

AU - Knoppers, Bartha M.

AU - Kwok, Pui Yan

AU - Licinio, Julio

AU - Long, Jeffrey C.

AU - Ossorio, Pilar

AU - Wang, Vivian Ota

AU - Rotimi, Charles N.

AU - Spallone, Patricia

AU - Terry, Sharon F.

AU - Lander, Eric S.

AU - Lai, Eric H.

AU - Nickerson, Deborah A.

AU - Abecasis, Gonçalo R.

AU - Altshuler, David

AU - Boehnke, Michael

AU - Deloukas, Panos

AU - Douglas, Julie A.

AU - Gabriel, Stacey B.

AU - Hudson, Richard R.

AU - Hudson, Thomas J.

AU - Kruglyak, Leonid

AU - Nakamura, Yusuke

AU - Nussbaum, Robert L.

AU - Schaffner, Stephen F.

AU - Sherry, Stephen T.

AU - Stein, Lincoln D.

AU - Tanaka, Toshihiro

PY - 2003/12/18

Y1 - 2003/12/18

N2 - The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of these patterns across the genome by determining the genotypes of one million or more sequence variants, their frequencies and the degree of association between them, in DNA samples from populations with ancestry from parts of Africa, Asia and Europe. The HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools, and will enhance our ability to choose targets for therapeutic intervention.

AB - The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of these patterns across the genome by determining the genotypes of one million or more sequence variants, their frequencies and the degree of association between them, in DNA samples from populations with ancestry from parts of Africa, Asia and Europe. The HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools, and will enhance our ability to choose targets for therapeutic intervention.

UR - https://www.scopus.com/pages/publications/79959503826

U2 - 10.1038/nature02168

DO - 10.1038/nature02168

M3 - 文章

AN - SCOPUS:79959503826

SN - 0028-0836

VL - 426

SP - 789

EP - 796

JO - Nature

JF - Nature

IS - 6968

ER -

The international HapMap project

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