The insights of Let-7 miRNAs in oncogenesis and stem cell potency

Xin Sun; Jian Liu; Chongwen Xu; Shou Ching Tang; Hong Ren

doi:10.1111/jcmm.12861

The insights of Let-7 miRNAs in oncogenesis and stem cell potency

Xin Sun
, Jian Liu
, Chongwen Xu
, Shou Ching Tang
, Hong Ren

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

Abstract

The ability of the classic tumour-suppressive let-7 family to inhibit carcinogenesis, tumour progression, recurrence and pluripotency of cancer stem cells has generated significant interest in the field of cancer research. Through suppressing and degrading downstream-targeted mRNAs, let-7 affected most aspects of cell biology. It is perplexing how let-7 affects oncogenesis, as the large influx of new miRNAs and other kinds of non-coding RNAs are continuously defined. In this review, we delineate the complex functions of let-7 and discuss the future direction of let-7 research.

Original language	English
Pages (from-to)	1779-1788
Number of pages	10
Journal	Journal of Cellular and Molecular Medicine
Volume	20
Issue number	9
DOIs	https://doi.org/10.1111/jcmm.12861
State	Published - 1 Sep 2016
Externally published	Yes

Keywords

DNA methylation
Let-7 miRNAs
anti-cancer research
cancer stem cells
clinical application
non-coding RNAs
regulatory loops

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/jcmm.12861

Cite this

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title = "The insights of Let-7 miRNAs in oncogenesis and stem cell potency",

abstract = "The ability of the classic tumour-suppressive let-7 family to inhibit carcinogenesis, tumour progression, recurrence and pluripotency of cancer stem cells has generated significant interest in the field of cancer research. Through suppressing and degrading downstream-targeted mRNAs, let-7 affected most aspects of cell biology. It is perplexing how let-7 affects oncogenesis, as the large influx of new miRNAs and other kinds of non-coding RNAs are continuously defined. In this review, we delineate the complex functions of let-7 and discuss the future direction of let-7 research.",

keywords = "DNA methylation, Let-7 miRNAs, anti-cancer research, cancer stem cells, clinical application, non-coding RNAs, regulatory loops",

author = "Xin Sun and Jian Liu and Chongwen Xu and Tang, \{Shou Ching\} and Hong Ren",

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AU - Sun, Xin

AU - Liu, Jian

AU - Xu, Chongwen

AU - Tang, Shou Ching

AU - Ren, Hong

PY - 2016/9/1

Y1 - 2016/9/1

N2 - The ability of the classic tumour-suppressive let-7 family to inhibit carcinogenesis, tumour progression, recurrence and pluripotency of cancer stem cells has generated significant interest in the field of cancer research. Through suppressing and degrading downstream-targeted mRNAs, let-7 affected most aspects of cell biology. It is perplexing how let-7 affects oncogenesis, as the large influx of new miRNAs and other kinds of non-coding RNAs are continuously defined. In this review, we delineate the complex functions of let-7 and discuss the future direction of let-7 research.

AB - The ability of the classic tumour-suppressive let-7 family to inhibit carcinogenesis, tumour progression, recurrence and pluripotency of cancer stem cells has generated significant interest in the field of cancer research. Through suppressing and degrading downstream-targeted mRNAs, let-7 affected most aspects of cell biology. It is perplexing how let-7 affects oncogenesis, as the large influx of new miRNAs and other kinds of non-coding RNAs are continuously defined. In this review, we delineate the complex functions of let-7 and discuss the future direction of let-7 research.

KW - DNA methylation

KW - Let-7 miRNAs

KW - anti-cancer research

KW - cancer stem cells

KW - clinical application

KW - non-coding RNAs

KW - regulatory loops

UR - https://www.scopus.com/pages/publications/84982273008

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DO - 10.1111/jcmm.12861

M3 - 文献综述

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AN - SCOPUS:84982273008

SN - 1582-1838

VL - 20

SP - 1779

EP - 1788

JO - Journal of Cellular and Molecular Medicine

JF - Journal of Cellular and Molecular Medicine

IS - 9

ER -

The insights of Let-7 miRNAs in oncogenesis and stem cell potency

Abstract

Keywords

UN SDGs

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