The global burden, trends and cross-country inequalities of female breast and gynaecologic cancers: A population based study

Liangxing Cheng; Zhihong Wang; Rufeng Li; Min Qiang; Chen Yang; Guoer Yang; Yingying Xie; Ruixia Yuan; Yungang Xu

doi:10.1111/1471-0528.17925

The global burden, trends and cross-country inequalities of female breast and gynaecologic cancers: A population based study

Liangxing Cheng
, Zhihong Wang
, Rufeng Li
, Min Qiang
, Chen Yang
, Guoer Yang
, Yingying Xie
, Ruixia Yuan
, Yungang Xu

Xi'an Jiaotong University
First Affiliated Hospital of Zhengzhou University
Department of Gynecology
Zhengzhou University
Department of Cell Biology and Genetics

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Objective: To analyse the global burden, trends and cross-country inequalities of female breast and gynaecologic cancers (FeBGCs). Design: Population-Based Study. Setting: Data sourced from the Global Burden of Disease Study 2019. Population: Individuals diagnosed with FeBGCs. Methods: Age-standardised mortality rates (ASMRs), age-standardised Disability-Adjusted Life Years (DALYs) rates (ASDRs) and their 95% uncertainty interval (UI) described the burden. Estimated annual percentage changes (EAPCs) and their confidence interval (CI) of age-standardised rates (ASRs) illustrated trends. Social inequalities were quantified using the Slope Index of Inequality (SII) and Concentration Index. Main Outcome Measures: The main outcome measures were the burden of FeBGCs and the trends in its inequalities over time. Results: In 2019, the ASDRs per 100 000 females were as follows: breast cancer: 473.83 (95% UI: 437.30–510.51), cervical cancer: 210.64 (95% UI: 177.67–234.85), ovarian cancer: 124.68 (95% UI: 109.13–138.67) and uterine cancer: 210.64 (95% UI: 177.67–234.85). The trends per year from 1990 to 2019 were expressed as EAPCs of ASDRs and these: for Breast cancer: −0.51 (95% CI: −0.57 to −0.45); Cervical cancer: −0.95 (95% CI: −0.99 to −0.89); Ovarian cancer: −0.08 (95% CI: −0.12 to −0.04); and Uterine cancer: −0.84 (95% CI: −0.93 to −0.75). In the Social Inequalities Analysis (1990–2019) the SII changed from 689.26 to 607.08 for Breast, from −226.66 to −239.92 for cervical, from 222.45 to 228.83 for ovarian and from 74.61 to 103.58 for uterine cancer. The concentration index values ranged from 0.2 to 0.4. Conclusions: The burden of FeBGCs worldwide showed a downward trend from 1990 to 2019. Countries or regions with higher Socio-demographic Index (SDI) bear a higher DALYs burden of breast, ovarian and uterine cancers, while those with lower SDI bear a heavier burden of cervical cancer. These inequalities increased over time.

Original language	English
Pages (from-to)	55-63
Number of pages	9
Journal	BJOG: An International Journal of Obstetrics and Gynaecology
Volume	132
Issue number	1
DOIs	https://doi.org/10.1111/1471-0528.17925
State	Published - Jan 2025
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

Keywords

disease burden
female breast and gynaecologic cancers
health equity analysis
temporal trend

Access to Document

10.1111/1471-0528.17925

Cite this

@article{341bdab6c5cb44729cc804cc90b37a9c,

title = "The global burden, trends and cross-country inequalities of female breast and gynaecologic cancers: A population based study",

abstract = "Objective: To analyse the global burden, trends and cross-country inequalities of female breast and gynaecologic cancers (FeBGCs). Design: Population-Based Study. Setting: Data sourced from the Global Burden of Disease Study 2019. Population: Individuals diagnosed with FeBGCs. Methods: Age-standardised mortality rates (ASMRs), age-standardised Disability-Adjusted Life Years (DALYs) rates (ASDRs) and their 95\% uncertainty interval (UI) described the burden. Estimated annual percentage changes (EAPCs) and their confidence interval (CI) of age-standardised rates (ASRs) illustrated trends. Social inequalities were quantified using the Slope Index of Inequality (SII) and Concentration Index. Main Outcome Measures: The main outcome measures were the burden of FeBGCs and the trends in its inequalities over time. Results: In 2019, the ASDRs per 100 000 females were as follows: breast cancer: 473.83 (95\% UI: 437.30–510.51), cervical cancer: 210.64 (95\% UI: 177.67–234.85), ovarian cancer: 124.68 (95\% UI: 109.13–138.67) and uterine cancer: 210.64 (95\% UI: 177.67–234.85). The trends per year from 1990 to 2019 were expressed as EAPCs of ASDRs and these: for Breast cancer: −0.51 (95\% CI: −0.57 to −0.45); Cervical cancer: −0.95 (95\% CI: −0.99 to −0.89); Ovarian cancer: −0.08 (95\% CI: −0.12 to −0.04); and Uterine cancer: −0.84 (95\% CI: −0.93 to −0.75). In the Social Inequalities Analysis (1990–2019) the SII changed from 689.26 to 607.08 for Breast, from −226.66 to −239.92 for cervical, from 222.45 to 228.83 for ovarian and from 74.61 to 103.58 for uterine cancer. The concentration index values ranged from 0.2 to 0.4. Conclusions: The burden of FeBGCs worldwide showed a downward trend from 1990 to 2019. Countries or regions with higher Socio-demographic Index (SDI) bear a higher DALYs burden of breast, ovarian and uterine cancers, while those with lower SDI bear a heavier burden of cervical cancer. These inequalities increased over time.",

keywords = "disease burden, female breast and gynaecologic cancers, health equity analysis, temporal trend",

author = "Liangxing Cheng and Zhihong Wang and Rufeng Li and Min Qiang and Chen Yang and Guoer Yang and Yingying Xie and Ruixia Yuan and Yungang Xu",

note = "Publisher Copyright: {\textcopyright} 2024 John Wiley \& Sons Ltd.",

year = "2025",

month = jan,

doi = "10.1111/1471-0528.17925",

language = "英语",

volume = "132",

pages = "55--63",

journal = "BJOG: An International Journal of Obstetrics and Gynaecology",

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T1 - The global burden, trends and cross-country inequalities of female breast and gynaecologic cancers

T2 - A population based study

AU - Cheng, Liangxing

AU - Wang, Zhihong

AU - Li, Rufeng

AU - Qiang, Min

AU - Yang, Chen

AU - Yang, Guoer

AU - Xie, Yingying

AU - Yuan, Ruixia

AU - Xu, Yungang

PY - 2025/1

Y1 - 2025/1

N2 - Objective: To analyse the global burden, trends and cross-country inequalities of female breast and gynaecologic cancers (FeBGCs). Design: Population-Based Study. Setting: Data sourced from the Global Burden of Disease Study 2019. Population: Individuals diagnosed with FeBGCs. Methods: Age-standardised mortality rates (ASMRs), age-standardised Disability-Adjusted Life Years (DALYs) rates (ASDRs) and their 95% uncertainty interval (UI) described the burden. Estimated annual percentage changes (EAPCs) and their confidence interval (CI) of age-standardised rates (ASRs) illustrated trends. Social inequalities were quantified using the Slope Index of Inequality (SII) and Concentration Index. Main Outcome Measures: The main outcome measures were the burden of FeBGCs and the trends in its inequalities over time. Results: In 2019, the ASDRs per 100 000 females were as follows: breast cancer: 473.83 (95% UI: 437.30–510.51), cervical cancer: 210.64 (95% UI: 177.67–234.85), ovarian cancer: 124.68 (95% UI: 109.13–138.67) and uterine cancer: 210.64 (95% UI: 177.67–234.85). The trends per year from 1990 to 2019 were expressed as EAPCs of ASDRs and these: for Breast cancer: −0.51 (95% CI: −0.57 to −0.45); Cervical cancer: −0.95 (95% CI: −0.99 to −0.89); Ovarian cancer: −0.08 (95% CI: −0.12 to −0.04); and Uterine cancer: −0.84 (95% CI: −0.93 to −0.75). In the Social Inequalities Analysis (1990–2019) the SII changed from 689.26 to 607.08 for Breast, from −226.66 to −239.92 for cervical, from 222.45 to 228.83 for ovarian and from 74.61 to 103.58 for uterine cancer. The concentration index values ranged from 0.2 to 0.4. Conclusions: The burden of FeBGCs worldwide showed a downward trend from 1990 to 2019. Countries or regions with higher Socio-demographic Index (SDI) bear a higher DALYs burden of breast, ovarian and uterine cancers, while those with lower SDI bear a heavier burden of cervical cancer. These inequalities increased over time.

AB - Objective: To analyse the global burden, trends and cross-country inequalities of female breast and gynaecologic cancers (FeBGCs). Design: Population-Based Study. Setting: Data sourced from the Global Burden of Disease Study 2019. Population: Individuals diagnosed with FeBGCs. Methods: Age-standardised mortality rates (ASMRs), age-standardised Disability-Adjusted Life Years (DALYs) rates (ASDRs) and their 95% uncertainty interval (UI) described the burden. Estimated annual percentage changes (EAPCs) and their confidence interval (CI) of age-standardised rates (ASRs) illustrated trends. Social inequalities were quantified using the Slope Index of Inequality (SII) and Concentration Index. Main Outcome Measures: The main outcome measures were the burden of FeBGCs and the trends in its inequalities over time. Results: In 2019, the ASDRs per 100 000 females were as follows: breast cancer: 473.83 (95% UI: 437.30–510.51), cervical cancer: 210.64 (95% UI: 177.67–234.85), ovarian cancer: 124.68 (95% UI: 109.13–138.67) and uterine cancer: 210.64 (95% UI: 177.67–234.85). The trends per year from 1990 to 2019 were expressed as EAPCs of ASDRs and these: for Breast cancer: −0.51 (95% CI: −0.57 to −0.45); Cervical cancer: −0.95 (95% CI: −0.99 to −0.89); Ovarian cancer: −0.08 (95% CI: −0.12 to −0.04); and Uterine cancer: −0.84 (95% CI: −0.93 to −0.75). In the Social Inequalities Analysis (1990–2019) the SII changed from 689.26 to 607.08 for Breast, from −226.66 to −239.92 for cervical, from 222.45 to 228.83 for ovarian and from 74.61 to 103.58 for uterine cancer. The concentration index values ranged from 0.2 to 0.4. Conclusions: The burden of FeBGCs worldwide showed a downward trend from 1990 to 2019. Countries or regions with higher Socio-demographic Index (SDI) bear a higher DALYs burden of breast, ovarian and uterine cancers, while those with lower SDI bear a heavier burden of cervical cancer. These inequalities increased over time.

KW - disease burden

KW - female breast and gynaecologic cancers

KW - health equity analysis

KW - temporal trend

UR - https://www.scopus.com/pages/publications/85200444439

U2 - 10.1111/1471-0528.17925

DO - 10.1111/1471-0528.17925

M3 - 文章

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AN - SCOPUS:85200444439

SN - 1470-0328

VL - 132

SP - 55

EP - 63

JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

IS - 1

ER -

The global burden, trends and cross-country inequalities of female breast and gynaecologic cancers: A population based study

Abstract

UN SDGs

Keywords

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