The fabrication and properties of poly (3-hydroxybutyrate-co-4- hydroxybutyrate) scaffolds by electrospinning for bone tissue engineering

In this study, poly (3-hydroxybutyrate-co-4-hydroxybutyrate) (PHB) electrospun film was fabricated by electrospinning. The morphology, mechanical properties, degradability and biocompatibility of the scaffold were investigated by SEM, XRD and tensile test etc. The morphology of mouse fibroblast cells (L929) cultured on PHB electrospun film was also studied, whioh provided the application of the bone tissue engineering with theoretical and experimental basis. Final results indicated that morphology of fibers can be influenced by varying the spinning parameters such as concentration of solution, solution flow rate, and distance of the electric field. Compared with cast film the crystallinity and the degradation rate of scaffolds increase remarkably but their tensile strength and the extension rate decrease. The morphology of the cells showed good biocompatibility of the scaffold. These properties make this scaffold a potential candidate as an electrospinning scaffold material for tissue engineering.