Abstract
Objective: To evaluate the expression and function of mammalian target of rapamycin (mTOR) and its substrate kinase P70S6K in mTOR/P70S6K signal pathway in cervical carcinogenesis. Methods: The expression of mTOR and P70S6K in normal cervix uteri or cervical cancer was detected by the immunohistochemistry and RT-PCR methods. Results: Compared to those in normal cervix uteri, both mRNA and protein of mTOR/P70S6K in cervical carcinomas were significantly increased (P<0.05). There was a positive correlation between mTOR gene and P70S6K gene expression in cervical cancer (r=0.746, P<0.001). Conclusion: High expression of mTOR and P7OS6K may play an important role in the pathogenesis and development of cervical cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 10-13 |
| Number of pages | 4 |
| Journal | Journal of Xi'an Jiaotong University (Medical Sciences) |
| Volume | 31 |
| Issue number | 1 |
| State | Published - Jan 2010 |
Keywords
- Cervical cancer
- Mammalian target of rapamycin (mTOR)
- P70S6K
