[The expression and clinical significance of Annexin II in clear-cell renal cell carcinoma].

To discuss the difference of annexinII expression between the Clear-Cell Renal Cell Carcinoma(ccRCC) and the corresponding normal renal tissues, and to reveal the clinical significance of Annexin II expression in ccRCC. Western blotting was used to detect the expression of Annexin II in 29 samples of fresh ccRCC and the corresponding normal renal tissues. Annexin II expression was examined in 120 samples of paraffin-embedding ccRCC and the corresponding normal renal tissues using immunohistochemistry. Correlations with Annexin IIexpression and clinic-pathological parameters were analyzed. There was expression of Annexin II in both ccRCC and the corresponding normal renal tissues. In ccRCC tissues, the total levels of Annexin II proteins were significantly higher than that in the corresponding normal renal tissues (P<0.01). The positive rate of AnnexinII expression in immunohistochemistry was 67.5% in the ccRCC tissues, existing significant difference compared with the corresponding normal renal tissues (P<0.01). Expression of Annexin II in ccRCC mainly showed membranous staining. Annexin II expression level was positively correlated with TNM stage (P<0.05), histology grade (P<0.05), renal capsule infiltration (P<0.01) and distant metastasis (P<0.01) of ccRCC. Moreover, Annexin II expression level was significantly correlated with ccRCC patients'5-years survival rate(P<0.01). Overexpression of AnnexinII in the ccRCC is closely correlated with the ccRCC development. It may play an important role in the process of ccRCC invasion and metastasis.