The effect of transforming growth factor-β1 on expression of SMAD3 and SMAD7 in keloid-derived fibroblasts

Li Yang; Huiyuan Li; Shuzhong Guo; Yan Han; Suyang Tang; Linxi Zhang; Maoguo Shu; Baohua Pan

The effect of transforming growth factor-β₁ on expression of SMAD3 and SMAD7 in keloid-derived fibroblasts

Li Yang
, Huiyuan Li
, Shuzhong Guo
, Yan Han
, Suyang Tang
, Linxi Zhang
, Maoguo Shu
, Baohua Pan

Xijing Hospital

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Aim: To study the expression of SMAD3 and SMAD7 of transforming growth factor-β₁ (TGF-β₁) on keloid-derived fibroblasts. Methods: The expression of SMAD3 (at 1, 2, 4, 24, 48 h) and SMAD7 (at 0.5 1, 1.5, 2, 4, 24 h) were detected by using methods of Western blot after 500 pmol/L TGF-β1 were added to the monolayer culture system. Results: The level of SMAD3 were down regulated at 24 h and the SMAD7 were maximum up regulated at 4 h when TGF-β ₁ were used. Conclusion: TGF-β₁ may down regulate the expression of SMAD3, but up regulate that of SMAD7.

Original language	English
Pages (from-to)	1006-1007
Number of pages	2
Journal	Chinese Journal of Clinical Rehabilitation
Volume	7
Issue number	6
State	Published - Mar 2003
Externally published	Yes

Keywords

Fibroblasts
Keloid
Transforming growth factor bata

Cite this

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title = "The effect of transforming growth factor-β1 on expression of SMAD3 and SMAD7 in keloid-derived fibroblasts",

abstract = "Aim: To study the expression of SMAD3 and SMAD7 of transforming growth factor-β1 (TGF-β1) on keloid-derived fibroblasts. Methods: The expression of SMAD3 (at 1, 2, 4, 24, 48 h) and SMAD7 (at 0.5 1, 1.5, 2, 4, 24 h) were detected by using methods of Western blot after 500 pmol/L TGF-β1 were added to the monolayer culture system. Results: The level of SMAD3 were down regulated at 24 h and the SMAD7 were maximum up regulated at 4 h when TGF-β 1 were used. Conclusion: TGF-β1 may down regulate the expression of SMAD3, but up regulate that of SMAD7.",

keywords = "Fibroblasts, Keloid, Transforming growth factor bata",

author = "Li Yang and Huiyuan Li and Shuzhong Guo and Yan Han and Suyang Tang and Linxi Zhang and Maoguo Shu and Baohua Pan",

year = "2003",

month = mar,

language = "英语",

volume = "7",

pages = "1006--1007",

journal = "Chinese Journal of Clinical Rehabilitation",

issn = "1671-5926",

publisher = "Publishing House of Chinese Journal of Tissue Engineering Research",

number = "6",

}

TY - JOUR

T1 - The effect of transforming growth factor-β1 on expression of SMAD3 and SMAD7 in keloid-derived fibroblasts

AU - Yang, Li

AU - Li, Huiyuan

AU - Guo, Shuzhong

AU - Han, Yan

AU - Tang, Suyang

AU - Zhang, Linxi

AU - Shu, Maoguo

AU - Pan, Baohua

PY - 2003/3

Y1 - 2003/3

N2 - Aim: To study the expression of SMAD3 and SMAD7 of transforming growth factor-β1 (TGF-β1) on keloid-derived fibroblasts. Methods: The expression of SMAD3 (at 1, 2, 4, 24, 48 h) and SMAD7 (at 0.5 1, 1.5, 2, 4, 24 h) were detected by using methods of Western blot after 500 pmol/L TGF-β1 were added to the monolayer culture system. Results: The level of SMAD3 were down regulated at 24 h and the SMAD7 were maximum up regulated at 4 h when TGF-β 1 were used. Conclusion: TGF-β1 may down regulate the expression of SMAD3, but up regulate that of SMAD7.

AB - Aim: To study the expression of SMAD3 and SMAD7 of transforming growth factor-β1 (TGF-β1) on keloid-derived fibroblasts. Methods: The expression of SMAD3 (at 1, 2, 4, 24, 48 h) and SMAD7 (at 0.5 1, 1.5, 2, 4, 24 h) were detected by using methods of Western blot after 500 pmol/L TGF-β1 were added to the monolayer culture system. Results: The level of SMAD3 were down regulated at 24 h and the SMAD7 were maximum up regulated at 4 h when TGF-β 1 were used. Conclusion: TGF-β1 may down regulate the expression of SMAD3, but up regulate that of SMAD7.

KW - Fibroblasts

KW - Keloid

KW - Transforming growth factor bata

UR - https://www.scopus.com/pages/publications/2442575699

M3 - 文章

AN - SCOPUS:2442575699

SN - 1671-5926

VL - 7

SP - 1006

EP - 1007

JO - Chinese Journal of Clinical Rehabilitation

JF - Chinese Journal of Clinical Rehabilitation

IS - 6

ER -

The effect of transforming growth factor-β₁ on expression of SMAD3 and SMAD7 in keloid-derived fibroblasts

Abstract

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