Abstract
Objective: To elucidate the relationship between fluoride and cell apoptosis of ameloblasts and to further study the mechanism of dental fluorosis. Methods: By establishing an experimental model of fluoride intoxication in pregnant C57BL/6N, we observed apoptosis in the fetal secretory ameloblasts in mice by means of transmission electron microscope and TUNEL. Results: High fluoride exposure in pregnant mice could cause subameloblastic cysts in first lower molar of fetal mice. Programmed cell death (PCD) occurred in the disturbed ameloblasts above cysts. Conclusion: Intoxication mechanism of fluoride on ameloblasts may occur by means of PCD.
| Original language | English |
|---|---|
| Pages (from-to) | 39-41 |
| Number of pages | 3 |
| Journal | Journal of Xi'an Jiaotong University (Medical Sciences) |
| Volume | 25 |
| Issue number | 1 |
| State | Published - Feb 2004 |
Keywords
- Ameloblast
- Apoptosis
- Fluoride