The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching

Junji Xu; Peter Zanvit; Lei Hu; Pang Yen Tseng; Na Liu; Fu Wang; Ousheng Liu; Dunfang Zhang; Wenwen Jin; Nancy Guo; Yichen Han; Jessica Yin; Alexander Cain; Mark A. Hoon; Songlin Wang; Wan Jun Chen

doi:10.1016/j.immuni.2020.06.023

The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching

Junji Xu
, Peter Zanvit
, Lei Hu
, Pang Yen Tseng
, Na Liu
, Fu Wang
, Ousheng Liu
, Dunfang Zhang
, Wenwen Jin
, Nancy Guo
, Yichen Han
, Jessica Yin
, Alexander Cain
, Mark A. Hoon
, Songlin Wang
, Wan Jun Chen

Health Science Center

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Xu et al. find that TGF-β, produced as part of the wound healing process, induces expression of interleukin-31 by dermal conventional type 2 DCs, which, in turn, increases neuron sensitivity and provokes itching.

Original language	English
Pages (from-to)	371-383.e5
Journal	Immunity
Volume	53
Issue number	2
DOIs	https://doi.org/10.1016/j.immuni.2020.06.023
State	Published - 18 Aug 2020

Keywords

dermal dendritic cells
interleukin-31
itch
neuro-immune interaction
transforming growth factor beta
wound healing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.immuni.2020.06.023

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Xu, J., Zanvit, P., Hu, L., Tseng, P. Y., Liu, N., Wang, F., Liu, O., Zhang, D., Jin, W., Guo, N., Han, Y., Yin, J., Cain, A., Hoon, M. A., Wang, S., & Chen, W. J. (2020). The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching. Immunity, 53(2), 371-383.e5. https://doi.org/10.1016/j.immuni.2020.06.023

@article{9e9e3b38683048c29c269f8865654890,

title = "The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching",

abstract = "Xu et al. find that TGF-β, produced as part of the wound healing process, induces expression of interleukin-31 by dermal conventional type 2 DCs, which, in turn, increases neuron sensitivity and provokes itching.",

keywords = "dermal dendritic cells, interleukin-31, itch, neuro-immune interaction, transforming growth factor beta, wound healing",

author = "Junji Xu and Peter Zanvit and Lei Hu and Tseng, \{Pang Yen\} and Na Liu and Fu Wang and Ousheng Liu and Dunfang Zhang and Wenwen Jin and Nancy Guo and Yichen Han and Jessica Yin and Alexander Cain and Hoon, \{Mark A.\} and Songlin Wang and Chen, \{Wan Jun\}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = aug,

day = "18",

doi = "10.1016/j.immuni.2020.06.023",

language = "英语",

volume = "53",

pages = "371--383.e5",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "2",

}

Xu, J, Zanvit, P, Hu, L, Tseng, PY, Liu, N, Wang, F, Liu, O, Zhang, D, Jin, W, Guo, N, Han, Y, Yin, J, Cain, A, Hoon, MA, Wang, S & Chen, WJ 2020, 'The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching', Immunity, vol. 53, no. 2, pp. 371-383.e5. https://doi.org/10.1016/j.immuni.2020.06.023

TY - JOUR

T1 - The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching

AU - Xu, Junji

AU - Zanvit, Peter

AU - Hu, Lei

AU - Tseng, Pang Yen

AU - Liu, Na

AU - Wang, Fu

AU - Liu, Ousheng

AU - Zhang, Dunfang

AU - Jin, Wenwen

AU - Guo, Nancy

AU - Han, Yichen

AU - Yin, Jessica

AU - Cain, Alexander

AU - Hoon, Mark A.

AU - Wang, Songlin

AU - Chen, Wan Jun

PY - 2020/8/18

Y1 - 2020/8/18

N2 - Xu et al. find that TGF-β, produced as part of the wound healing process, induces expression of interleukin-31 by dermal conventional type 2 DCs, which, in turn, increases neuron sensitivity and provokes itching.

AB - Xu et al. find that TGF-β, produced as part of the wound healing process, induces expression of interleukin-31 by dermal conventional type 2 DCs, which, in turn, increases neuron sensitivity and provokes itching.

KW - dermal dendritic cells

KW - interleukin-31

KW - itch

KW - neuro-immune interaction

KW - transforming growth factor beta

KW - wound healing

UR - https://www.scopus.com/pages/publications/85089067162

U2 - 10.1016/j.immuni.2020.06.023

DO - 10.1016/j.immuni.2020.06.023

M3 - 文章

C2 - 32673566

AN - SCOPUS:85089067162

SN - 1074-7613

VL - 53

SP - 371-383.e5

JO - Immunity

JF - Immunity

IS - 2

ER -

The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching

Abstract

Keywords

UN SDGs

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