The cause of ratio of CD4/+/CD8/+ turning over in TIL of glioma

B. Gang; L. Shouxun; W. Maode

The cause of ratio of CD₄/⁺/CD₈/⁺ turning over in TIL of glioma

B. Gang
, L. Shouxun
, W. Maode

The First Affiliated Hospital of Xi’an Jiaotong University

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To find out how the tumor's microenvironment changes the ratio of TIL. Methods: This research observed the effects of substance of glioma on PBMC of normal persons. Results: The results showed that the substance of tumor could inhibit the effect of PHA to proliferate the PBMC and produce IL-2. Such effects could not be reversed by exogenous IL-2. Conclusion: (1) Tumor cells grow up and injure the blood-brain-barrier; (2) T lymphocytes infiltrate into the tumor randomly; (3) Tumor cells secret some inhibitors to inhibit the production of IL-2 and CD₄/⁺ subgroup proliferation.

Original language	English
Pages (from-to)	336-338
Number of pages	3
Journal	Journal of Xi'an Medical University, Chinese Edition
Volume	21
Issue number	4
State	Published - 2000
Externally published	Yes

Keywords

Glioma
Tumor infiltative lymphocyte
Tumor's microenvironment

Cite this

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title = "The cause of ratio of CD4/+/CD8/+ turning over in TIL of glioma",

abstract = "Objective: To find out how the tumor's microenvironment changes the ratio of TIL. Methods: This research observed the effects of substance of glioma on PBMC of normal persons. Results: The results showed that the substance of tumor could inhibit the effect of PHA to proliferate the PBMC and produce IL-2. Such effects could not be reversed by exogenous IL-2. Conclusion: (1) Tumor cells grow up and injure the blood-brain-barrier; (2) T lymphocytes infiltrate into the tumor randomly; (3) Tumor cells secret some inhibitors to inhibit the production of IL-2 and CD4/+ subgroup proliferation.",

keywords = "Glioma, Tumor infiltative lymphocyte, Tumor's microenvironment",

author = "B. Gang and L. Shouxun and W. Maode",

year = "2000",

language = "英语",

volume = "21",

pages = "336--338",

journal = "Journal of Xi'an Medical University, Chinese Edition",

issn = "0258-0659",

publisher = "Xi'an Medical University",

number = "4",

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TY - JOUR

T1 - The cause of ratio of CD4/+/CD8/+ turning over in TIL of glioma

AU - Gang, B.

AU - Shouxun, L.

AU - Maode, W.

PY - 2000

Y1 - 2000

N2 - Objective: To find out how the tumor's microenvironment changes the ratio of TIL. Methods: This research observed the effects of substance of glioma on PBMC of normal persons. Results: The results showed that the substance of tumor could inhibit the effect of PHA to proliferate the PBMC and produce IL-2. Such effects could not be reversed by exogenous IL-2. Conclusion: (1) Tumor cells grow up and injure the blood-brain-barrier; (2) T lymphocytes infiltrate into the tumor randomly; (3) Tumor cells secret some inhibitors to inhibit the production of IL-2 and CD4/+ subgroup proliferation.

AB - Objective: To find out how the tumor's microenvironment changes the ratio of TIL. Methods: This research observed the effects of substance of glioma on PBMC of normal persons. Results: The results showed that the substance of tumor could inhibit the effect of PHA to proliferate the PBMC and produce IL-2. Such effects could not be reversed by exogenous IL-2. Conclusion: (1) Tumor cells grow up and injure the blood-brain-barrier; (2) T lymphocytes infiltrate into the tumor randomly; (3) Tumor cells secret some inhibitors to inhibit the production of IL-2 and CD4/+ subgroup proliferation.

KW - Glioma

KW - Tumor infiltative lymphocyte

KW - Tumor's microenvironment

UR - https://www.scopus.com/pages/publications/0033805093

M3 - 文章

AN - SCOPUS:0033805093

SN - 0258-0659

VL - 21

SP - 336

EP - 338

JO - Journal of Xi'an Medical University, Chinese Edition

JF - Journal of Xi'an Medical University, Chinese Edition

IS - 4

ER -

The cause of ratio of CD₄/⁺/CD₈/⁺ turning over in TIL of glioma

Abstract

Keywords

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