TY - JOUR
T1 - The association of maternal dietary folate intake and folic acid supplementation with small-for-gestational-age births
T2 - A cross-sectional study in Northwest China
AU - Li, Shanshan
AU - Liu, Danmeng
AU - Zhang, Ruo
AU - Lei, Fangliang
AU - Liu, Xin
AU - Cheng, Yue
AU - Li, Chao
AU - Xiao, Mengyao
AU - Guo, Leqian
AU - Li, Minmin
AU - Zhang, Binyan
AU - Zhu, Zhonghai
AU - Shi, Guoshuai
AU - Liu, Yezhou
AU - Dang, Shaonong
AU - Yan, Hong
N1 - Publisher Copyright:
© The Authors 2019.
PY - 2019/8/28
Y1 - 2019/8/28
N2 - The effect of maternal folate intake on small-for-gestational-age (SGA) births remains inconclusive. The present study aimed to investigate the associations of maternal folate intake from diet and supplements with the risk of SGA births using data from a cross-sectional study in Shaanxi Province of Northwest China. A total of 7307 women who were within 12 months (median 3; 10th-90th percentile 0-7) after delivery were included. Two-level models were adopted to examine the associations of folate (dietary folate, supplemental folic acid and total folate) intake with the risk of SGA births and birth weight Z score, controlling for a minimum set of confounders that were identified in a directed acyclic graph. Results showed that a higher supplemental folic acid intake during the first trimester was negatively associated with the risk of SGA births (≤60 d v. non-use: OR 0·80; 95 % CI 0·66, 0·96; >60 d v. non-use: OR 0·78; 95 % CI 0·65, 0·94; Ptrend = 0·010; per 10-d increase: OR 0·97; 95 % CI 0·95, 0·99). A higher total folate intake during pregnancy was associated with a reduced risk of SGA births (highest tertile v. lowest tertile: OR 0·77; 95 % CI 0·64, 0·94; Ptrend = 0·010; per one-unit increase in the log-transformed value: OR 0·81; 95 % CI 0·69, 0·95). A similar pattern was observed for the birth weight Z score. Our study suggested that folic acid supplementation during the first trimester and a higher total folate intake during pregnancy were associated with a reduced risk of SGA births.
AB - The effect of maternal folate intake on small-for-gestational-age (SGA) births remains inconclusive. The present study aimed to investigate the associations of maternal folate intake from diet and supplements with the risk of SGA births using data from a cross-sectional study in Shaanxi Province of Northwest China. A total of 7307 women who were within 12 months (median 3; 10th-90th percentile 0-7) after delivery were included. Two-level models were adopted to examine the associations of folate (dietary folate, supplemental folic acid and total folate) intake with the risk of SGA births and birth weight Z score, controlling for a minimum set of confounders that were identified in a directed acyclic graph. Results showed that a higher supplemental folic acid intake during the first trimester was negatively associated with the risk of SGA births (≤60 d v. non-use: OR 0·80; 95 % CI 0·66, 0·96; >60 d v. non-use: OR 0·78; 95 % CI 0·65, 0·94; Ptrend = 0·010; per 10-d increase: OR 0·97; 95 % CI 0·95, 0·99). A higher total folate intake during pregnancy was associated with a reduced risk of SGA births (highest tertile v. lowest tertile: OR 0·77; 95 % CI 0·64, 0·94; Ptrend = 0·010; per one-unit increase in the log-transformed value: OR 0·81; 95 % CI 0·69, 0·95). A similar pattern was observed for the birth weight Z score. Our study suggested that folic acid supplementation during the first trimester and a higher total folate intake during pregnancy were associated with a reduced risk of SGA births.
KW - Dietary folate
KW - Folic acid supplements
KW - Pregnancy
KW - Small-for-gestational-age births
UR - https://www.scopus.com/pages/publications/85070274265
U2 - 10.1017/S0007114519001272
DO - 10.1017/S0007114519001272
M3 - 文章
C2 - 31379315
AN - SCOPUS:85070274265
SN - 0007-1145
VL - 122
SP - 459
EP - 467
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 4
ER -