TY - CHAP
T1 - Targeting SCF E3 Ligases for Cancer Therapies
AU - Liu, Jing
AU - Peng, Yunhua
AU - Zhang, Jinfang
AU - Long, Jiangang
AU - Liu, Jiankang
AU - Wei, Wenyi
N1 - Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2020.
PY - 2020
Y1 - 2020
N2 - SKP1-cullin-1-F-box-protein (SCF) E3 ubiquitin ligase complex is responsible for the degradation of proteins in a strictly regulated manner, through which it exerts pivotal roles in regulating various key cellular processes including cell cycle and division, apoptosis, and differentiation. The substrate specificity of the SCF complex largely depends on the distinct F-box proteins, which function in either tumor promotion or suppression or in a context-dependent manner. Among the 69 F-box proteins identified in human genome, FBW7, SKP2, and β-TRCP have been extensively investigated among various types of cancer in respective of their roles in cancer development, progression, and metastasis. Moreover, several specific inhibitors have been developed to target those E3 ligases, and their efficiency in tumors has been determined. In this review, we provide a summary of the roles of SCF E3 ligases in cancer development, as well as the potential application of miRNA or specific inhibitors for cancer therapy.
AB - SKP1-cullin-1-F-box-protein (SCF) E3 ubiquitin ligase complex is responsible for the degradation of proteins in a strictly regulated manner, through which it exerts pivotal roles in regulating various key cellular processes including cell cycle and division, apoptosis, and differentiation. The substrate specificity of the SCF complex largely depends on the distinct F-box proteins, which function in either tumor promotion or suppression or in a context-dependent manner. Among the 69 F-box proteins identified in human genome, FBW7, SKP2, and β-TRCP have been extensively investigated among various types of cancer in respective of their roles in cancer development, progression, and metastasis. Moreover, several specific inhibitors have been developed to target those E3 ligases, and their efficiency in tumors has been determined. In this review, we provide a summary of the roles of SCF E3 ligases in cancer development, as well as the potential application of miRNA or specific inhibitors for cancer therapy.
KW - Cancer
KW - FBW7
KW - SCF E3 ligase
KW - SKP2
KW - β-TRCP
UR - https://www.scopus.com/pages/publications/85077464344
U2 - 10.1007/978-981-15-1025-0_9
DO - 10.1007/978-981-15-1025-0_9
M3 - 章节
C2 - 31898226
AN - SCOPUS:85077464344
T3 - Advances in Experimental Medicine and Biology
SP - 123
EP - 146
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -
