Targeting PFKFB3 in the Endothelium for Cancer Therapy

Qi Yang; Peng Hou

doi:10.1016/j.molmed.2017.01.008

Targeting PFKFB3 in the Endothelium for Cancer Therapy

Qi Yang
, Peng Hou

The First Affiliated Hospital of Xi’an Jiaotong University

Research output: Contribution to journal › Short survey › peer-review

13 Scopus citations

Abstract

In a recent article published in Cancer Cell, Cantelmo et al. showed that inhibition of endothelium glycolysis by targeting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) significantly impaired tumor metastasis by normalizing tumor vessels. In addition, as a promising therapeutic strategy, tumor vessel normalization by PFKFB3 blockade also improved the delivery and efficacy of chemotherapy.

Original language	English
Pages (from-to)	197-200
Number of pages	4
Journal	Trends in Molecular Medicine
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/j.molmed.2017.01.008
State	Published - 1 Mar 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.molmed.2017.01.008

Cite this

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title = "Targeting PFKFB3 in the Endothelium for Cancer Therapy",

abstract = "In a recent article published in Cancer Cell, Cantelmo et al. showed that inhibition of endothelium glycolysis by targeting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) significantly impaired tumor metastasis by normalizing tumor vessels. In addition, as a promising therapeutic strategy, tumor vessel normalization by PFKFB3 blockade also improved the delivery and efficacy of chemotherapy.",

author = "Qi Yang and Peng Hou",

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year = "2017",

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T1 - Targeting PFKFB3 in the Endothelium for Cancer Therapy

AU - Yang, Qi

AU - Hou, Peng

PY - 2017/3/1

Y1 - 2017/3/1

N2 - In a recent article published in Cancer Cell, Cantelmo et al. showed that inhibition of endothelium glycolysis by targeting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) significantly impaired tumor metastasis by normalizing tumor vessels. In addition, as a promising therapeutic strategy, tumor vessel normalization by PFKFB3 blockade also improved the delivery and efficacy of chemotherapy.

AB - In a recent article published in Cancer Cell, Cantelmo et al. showed that inhibition of endothelium glycolysis by targeting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) significantly impaired tumor metastasis by normalizing tumor vessels. In addition, as a promising therapeutic strategy, tumor vessel normalization by PFKFB3 blockade also improved the delivery and efficacy of chemotherapy.

UR - https://www.scopus.com/pages/publications/85011325645

U2 - 10.1016/j.molmed.2017.01.008

DO - 10.1016/j.molmed.2017.01.008

M3 - 短篇评述

C2 - 28173976

AN - SCOPUS:85011325645

SN - 1471-4914

VL - 23

SP - 197

EP - 200

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

IS - 3

ER -

Targeting PFKFB3 in the Endothelium for Cancer Therapy

Abstract

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