Targeting IL-4/IL-13 Signaling Pathways in Chronic Rhinosinusitis with Nasal Polyps: From Mechanisms to Therapies

Jiani Chen; Chen Zhang; Qianqian Zhang; Fuying Cheng; Yizhang Wang; Shirui Xue; Yufei Yang; Wenwen Guo; Juan Liu; Kai Xue; Yaguang Zhang; Dehui Wang; Li Hu; Huan Wang; Xicai Sun

doi:10.1007/s12016-025-09097-4

Targeting IL-4/IL-13 Signaling Pathways in Chronic Rhinosinusitis with Nasal Polyps: From Mechanisms to Therapies

Jiani Chen
, Chen Zhang
, Qianqian Zhang
, Fuying Cheng
, Yizhang Wang
, Shirui Xue
, Yufei Yang
, Wenwen Guo
, Juan Liu
, Kai Xue
, Yaguang Zhang
, Dehui Wang
, Li Hu
, Huan Wang
, Xicai Sun

Health Science Center

Eye & Ent Hospital of Fudan University
The First Affiliated Hospital of Xi’an Jiaotong University
People’s Hospital of Shigatse City

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper airway inflammatory disorder, characterized by persistent inflammation of the sinonasal mucosa and nasal polyp formation. The pivotal roles of interleukin (IL)-4/IL-13 signaling in CRSwNP pathogenesis is increasingly recognized, evidenced by the remarkable clinical success of biologics targeting this pathway. This review provides a concise overview of the IL-4/IL-13 pathway in CRSwNP, encompassing its molecular architecture, pathogenic mechanisms, current targeted therapies, and emerging therapeutic strategies.

Original language	English
Article number	87
Journal	Clinical Reviews in Allergy and Immunology
Volume	68
Issue number	1
DOIs	https://doi.org/10.1007/s12016-025-09097-4
State	Published - Dec 2025

Keywords

Chronic rhinosinusitis with nasal polyps
Interleukin-13
Interleukin-4
Type 2 inflammation

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10.1007/s12016-025-09097-4

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Chen, J., Zhang, C., Zhang, Q., Cheng, F., Wang, Y., Xue, S., Yang, Y., Guo, W., Liu, J., Xue, K., Zhang, Y., Wang, D., Hu, L., Wang, H., & Sun, X. (2025). Targeting IL-4/IL-13 Signaling Pathways in Chronic Rhinosinusitis with Nasal Polyps: From Mechanisms to Therapies. Clinical Reviews in Allergy and Immunology, 68(1), Article 87. https://doi.org/10.1007/s12016-025-09097-4

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title = "Targeting IL-4/IL-13 Signaling Pathways in Chronic Rhinosinusitis with Nasal Polyps: From Mechanisms to Therapies",

abstract = "Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper airway inflammatory disorder, characterized by persistent inflammation of the sinonasal mucosa and nasal polyp formation. The pivotal roles of interleukin (IL)-4/IL-13 signaling in CRSwNP pathogenesis is increasingly recognized, evidenced by the remarkable clinical success of biologics targeting this pathway. This review provides a concise overview of the IL-4/IL-13 pathway in CRSwNP, encompassing its molecular architecture, pathogenic mechanisms, current targeted therapies, and emerging therapeutic strategies.",

keywords = "Chronic rhinosinusitis with nasal polyps, Interleukin-13, Interleukin-4, Type 2 inflammation",

author = "Jiani Chen and Chen Zhang and Qianqian Zhang and Fuying Cheng and Yizhang Wang and Shirui Xue and Yufei Yang and Wenwen Guo and Juan Liu and Kai Xue and Yaguang Zhang and Dehui Wang and Li Hu and Huan Wang and Xicai Sun",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.",

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doi = "10.1007/s12016-025-09097-4",

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T1 - Targeting IL-4/IL-13 Signaling Pathways in Chronic Rhinosinusitis with Nasal Polyps

T2 - From Mechanisms to Therapies

AU - Chen, Jiani

AU - Zhang, Chen

AU - Zhang, Qianqian

AU - Cheng, Fuying

AU - Wang, Yizhang

AU - Xue, Shirui

AU - Yang, Yufei

AU - Guo, Wenwen

AU - Liu, Juan

AU - Xue, Kai

AU - Zhang, Yaguang

AU - Wang, Dehui

AU - Hu, Li

AU - Wang, Huan

AU - Sun, Xicai

N1 - Publisher Copyright: © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.

PY - 2025/12

Y1 - 2025/12

N2 - Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper airway inflammatory disorder, characterized by persistent inflammation of the sinonasal mucosa and nasal polyp formation. The pivotal roles of interleukin (IL)-4/IL-13 signaling in CRSwNP pathogenesis is increasingly recognized, evidenced by the remarkable clinical success of biologics targeting this pathway. This review provides a concise overview of the IL-4/IL-13 pathway in CRSwNP, encompassing its molecular architecture, pathogenic mechanisms, current targeted therapies, and emerging therapeutic strategies.

AB - Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper airway inflammatory disorder, characterized by persistent inflammation of the sinonasal mucosa and nasal polyp formation. The pivotal roles of interleukin (IL)-4/IL-13 signaling in CRSwNP pathogenesis is increasingly recognized, evidenced by the remarkable clinical success of biologics targeting this pathway. This review provides a concise overview of the IL-4/IL-13 pathway in CRSwNP, encompassing its molecular architecture, pathogenic mechanisms, current targeted therapies, and emerging therapeutic strategies.

KW - Chronic rhinosinusitis with nasal polyps

KW - Interleukin-13

KW - Interleukin-4

KW - Type 2 inflammation

UR - https://www.scopus.com/pages/publications/105016650539

U2 - 10.1007/s12016-025-09097-4

DO - 10.1007/s12016-025-09097-4

M3 - 文献综述

C2 - 40965572

AN - SCOPUS:105016650539

SN - 1080-0549

VL - 68

JO - Clinical Reviews in Allergy and Immunology

JF - Clinical Reviews in Allergy and Immunology

IS - 1

M1 - 87

ER -

Targeting IL-4/IL-13 Signaling Pathways in Chronic Rhinosinusitis with Nasal Polyps: From Mechanisms to Therapies

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Keywords

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