Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy

Di Gao; Ting Chen; Shuojia Chen; Xuechun Ren; Yulong Han; Yiwei Li; Ying Wang; Xiaoqing Guo; Hao Wang; Xing Chen; Ming Guo; Yu Shrike Zhang; Guosong Hong; Xingcai Zhang; Zhongmin Tian; Zhe Yang

doi:10.1007/s40820-021-00616-4

Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy

Di Gao
, Ting Chen
, Shuojia Chen
, Xuechun Ren
, Yulong Han
, Yiwei Li
, Ying Wang
, Xiaoqing Guo
, Hao Wang
, Xing Chen
, Ming Guo
, Yu Shrike Zhang
, Guosong Hong
, Xingcai Zhang
, Zhongmin Tian
, Zhe Yang

School of Life Science and Technology (SLST)

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

An all-organic hybrid nanobullets labeled as ZPA@HA-ACVA-AZ NBs was developed for the “precise strike”of hypoxic tumors through an oxygen-independently synergistic PTT/TDT, possessing therapeutic advantages over traditional ROS-mediated cancer treatment.By feat of dual-targeting effect from surface-modified HA (targeting CD44 receptors) and AZ (targeting CA IX), the nanobullets accumulated at hypoxic tumors efficiently.The synergism of intelligent nanobullets could suppress the primary breast tumor growth and lung metastasis via CA IX inhibition by AZ and synergistic PTT/TDT.

Original language	English
Article number	99
Journal	Nano-Micro Letters
Volume	13
Issue number	1
DOIs	https://doi.org/10.1007/s40820-021-00616-4
State	Published - Dec 2021

Keywords

Hypoxia tumor
Photothermal therapy (PTT)
Targeting hybrid nanobullet
Thermodynamic therapy (TDT)
Zinc phthalocyanine aggregate (ZPA)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s40820-021-00616-4

Cite this

Gao, D., Chen, T., Chen, S., Ren, X., Han, Y., Li, Y., Wang, Y., Guo, X., Wang, H., Chen, X., Guo, M., Zhang, Y. S., Hong, G., Zhang, X., Tian, Z., & Yang, Z. (2021). Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy. Nano-Micro Letters, 13(1), Article 99. https://doi.org/10.1007/s40820-021-00616-4

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abstract = "An all-organic hybrid nanobullets labeled as ZPA@HA-ACVA-AZ NBs was developed for the “precise strike”of hypoxic tumors through an oxygen-independently synergistic PTT/TDT, possessing therapeutic advantages over traditional ROS-mediated cancer treatment.By feat of dual-targeting effect from surface-modified HA (targeting CD44 receptors) and AZ (targeting CA IX), the nanobullets accumulated at hypoxic tumors efficiently.The synergism of intelligent nanobullets could suppress the primary breast tumor growth and lung metastasis via CA IX inhibition by AZ and synergistic PTT/TDT.",

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AU - Gao, Di

AU - Chen, Ting

AU - Chen, Shuojia

AU - Ren, Xuechun

AU - Han, Yulong

AU - Li, Yiwei

AU - Wang, Ying

AU - Guo, Xiaoqing

AU - Wang, Hao

AU - Chen, Xing

AU - Guo, Ming

AU - Zhang, Yu Shrike

AU - Hong, Guosong

AU - Zhang, Xingcai

AU - Tian, Zhongmin

AU - Yang, Zhe

PY - 2021/12

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AB - An all-organic hybrid nanobullets labeled as ZPA@HA-ACVA-AZ NBs was developed for the “precise strike”of hypoxic tumors through an oxygen-independently synergistic PTT/TDT, possessing therapeutic advantages over traditional ROS-mediated cancer treatment.By feat of dual-targeting effect from surface-modified HA (targeting CD44 receptors) and AZ (targeting CA IX), the nanobullets accumulated at hypoxic tumors efficiently.The synergism of intelligent nanobullets could suppress the primary breast tumor growth and lung metastasis via CA IX inhibition by AZ and synergistic PTT/TDT.

KW - Hypoxia tumor

KW - Photothermal therapy (PTT)

KW - Targeting hybrid nanobullet

KW - Thermodynamic therapy (TDT)

KW - Zinc phthalocyanine aggregate (ZPA)

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