Tailoring highly branched poly(β-amino ester)s: A synthetic platform for epidermal gene therapy

Jian Yuan Huang; Yongsheng Gao; Lara Cutlar; Jonathan O'Keeffe-Ahern; Tianyu Zhao; Feng Huei Lin; Dezhong Zhou; Sean McMahon; Udo Greiser; Wei Wang; Wenxin Wang

doi:10.1039/c5cc02193f

Tailoring highly branched poly(β-amino ester)s: A synthetic platform for epidermal gene therapy

Jian Yuan Huang
, Yongsheng Gao
, Lara Cutlar
, Jonathan O'Keeffe-Ahern
, Tianyu Zhao
, Feng Huei Lin
, Dezhong Zhou
, Sean McMahon
, Udo Greiser
, Wei Wang
, Wenxin Wang

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Highly branched poly(β-amino ester)s (HPAEs) were designed and synthesised for safe and efficient gene delivery to human keratinocytes. HPAEs outperformed commercial transfection reagents: PEI and SuperFect®, for both transfection efficiency and biocompatibility. A 22 and 3.4 fold enhancement of gene transfection was seen coupled with superior biocompatibility.

Original language	English
Pages (from-to)	8473-8476
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	40
DOIs	https://doi.org/10.1039/c5cc02193f
State	Published - 18 May 2015
Externally published	Yes

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10.1039/c5cc02193f

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title = "Tailoring highly branched poly(β-amino ester)s: A synthetic platform for epidermal gene therapy",

abstract = "Highly branched poly(β-amino ester)s (HPAEs) were designed and synthesised for safe and efficient gene delivery to human keratinocytes. HPAEs outperformed commercial transfection reagents: PEI and SuperFect{\textregistered}, for both transfection efficiency and biocompatibility. A 22 and 3.4 fold enhancement of gene transfection was seen coupled with superior biocompatibility.",

author = "Huang, \{Jian Yuan\} and Yongsheng Gao and Lara Cutlar and Jonathan O'Keeffe-Ahern and Tianyu Zhao and Lin, \{Feng Huei\} and Dezhong Zhou and Sean McMahon and Udo Greiser and Wei Wang and Wenxin Wang",

note = "Publisher Copyright: {\textcopyright} 2015 The Royal Society of Chemistry.",

year = "2015",

month = may,

day = "18",

doi = "10.1039/c5cc02193f",

language = "英语",

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journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Tailoring highly branched poly(β-amino ester)s

T2 - A synthetic platform for epidermal gene therapy

AU - Huang, Jian Yuan

AU - Gao, Yongsheng

AU - Cutlar, Lara

AU - O'Keeffe-Ahern, Jonathan

AU - Zhao, Tianyu

AU - Lin, Feng Huei

AU - Zhou, Dezhong

AU - McMahon, Sean

AU - Greiser, Udo

AU - Wang, Wei

AU - Wang, Wenxin

PY - 2015/5/18

Y1 - 2015/5/18

N2 - Highly branched poly(β-amino ester)s (HPAEs) were designed and synthesised for safe and efficient gene delivery to human keratinocytes. HPAEs outperformed commercial transfection reagents: PEI and SuperFect®, for both transfection efficiency and biocompatibility. A 22 and 3.4 fold enhancement of gene transfection was seen coupled with superior biocompatibility.

AB - Highly branched poly(β-amino ester)s (HPAEs) were designed and synthesised for safe and efficient gene delivery to human keratinocytes. HPAEs outperformed commercial transfection reagents: PEI and SuperFect®, for both transfection efficiency and biocompatibility. A 22 and 3.4 fold enhancement of gene transfection was seen coupled with superior biocompatibility.

UR - https://www.scopus.com/pages/publications/84928978337

U2 - 10.1039/c5cc02193f

DO - 10.1039/c5cc02193f

M3 - 文章

C2 - 25892461

AN - SCOPUS:84928978337

SN - 1359-7345

VL - 51

SP - 8473

EP - 8476

JO - Chemical Communications

JF - Chemical Communications

IS - 40

ER -

Tailoring highly branched poly(β-amino ester)s: A synthetic platform for epidermal gene therapy

Abstract

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