¹⁸F⁃FDG PET/CT 对早期活动性大动脉炎的诊断价值分析

【Abstract】 Objective This paper investigates the diagnostic value of ¹⁸F ‐ fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography(CT) in patients with early active takayasu arteritis (TA). Methods A case‐control study was conducted. The clinical data of 10 patients with TA who underwent PET/CT examination in the First Affiliated Hospital of Xi 'an Jiaotong University from January 2020 to December 2022, 2 males and 8 females, aged 20−72 (44.9±17.7) years, were included in the TA group, and 10 age‐ and gender‐matched patients without TA were part of the control group. The ¹⁸F‐FDG PET/CT imaging results of the two groups were observed, and the vascular lesions were delineated by two experienced radiologists. The maximum standardized uptake value (SUVmax) of the vessel wall was measured in the TA group and the control group, and the differences of the SUVmax between the two groups were compared. Spearman correlation analysis was used to explore the relationship between the SUVmax of the diseased artery wall and erythrocyte sedimentation rate (ESR) and C‐reactive protein (CRP) in the TA group. Results ¹⁸F‐FDG PET/CT imaging showed mild to moderate increase in glucose metabolism of aorta and its branch vessel walls in the 10 patients with TA. The SUVmax of large arteries in the TA group was 3.38± 0.85, which was significantly higher than that in the control group 1.68±0.24 (t=6.12, P<0.001). In the TA group, the SUVmax of large arteries was not correlated with ESR (r_s=0.489, P=0.151) but was positively correlated with CRP (r_s=0.758, P=0.011), and no correlation existed between ESR and CRP (r_s=0.479, P= 0.162). Conclusion ¹⁸F‐FDG PET/CT can accurately reflect the extent of TA lesions and the activity of TA through the SUVmax of the vessel wall, which is a reliable imaging method for the diagnosis of early active TA.