¹⁵³Sm-EDTMP and ibandronate monosodium used for cancer patients to alleviate multiple bone metastasis pain

Aim. To investigate the effect of ¹⁵³Sm-EDTMP and ibandronate monosodium in alleviating multiple bone metastasis pain of the patients with cancer. Methods. ¹⁵³Sm-EDTMP combined with ibandronate monosodium treatment was performed to observe the remission of bone pain and the improvement of quality of life (QOL) in 106 patients with cancer, 60 males and 46 females with an average age of 55 years (aged 29-67), including 36 cases of mammary cancer, 22 cases of lung cancer, 5 cases of pancreatic cancer, 9 cases of gastric carcinoma, 7 cases of hepatocarcinoma, 12 cases of large intestine cancer, 11 cases of prostate carcinoma and 4 cases of lymphoma. Results. Severe cases included 23 of CR, 16 of PR, 3 of MR and 3 of NR; moderate cases included 18 of CR, 15 of PR, 3 of MR and 2 of NR; mild cases included 14 of CR, 7 of PR and 2 of NR. The effective rate of pain relieving was 87.7% (93/106), and quality of life was significantly improved. No fatal toxic effects occurred. Conclusion. ¹⁵³Sm-EDTMP combined with ibandronate monosodium treatment for cancer multiple bone metastasis is effective and reliable.