Sulfated modification and immunomodulatory activity of water-soluble polysaccharides derived from fresh Chinese persimmon fruit

Yali Zhang; Xiaoyun Lu; Yuning Zhang; Liguo Qin; Jianbao Zhang

doi:10.1016/j.ijbiomac.2009.10.007

Sulfated modification and immunomodulatory activity of water-soluble polysaccharides derived from fresh Chinese persimmon fruit

Yali Zhang
, Xiaoyun Lu
, Yuning Zhang
, Liguo Qin
, Jianbao Zhang

Key Lab of the Ministry of Education for Process Control and Efficiency Egineering

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

In this study, three kinds of chemically sulfated polysaccharides (PFP-S) were derived from a water-soluble polysaccharide of persimmon fruit with chlorosulfonic acid-pyridine method. Relationship between the degree of substitution and immunomodulatory activity of PFP-S was examined with the splenocytes experiment. The results showed that the splenocytes-activating activity was significantly enhanced by PFP-S in all the groups compared with control group (P < 0.01). PFP-SII exhibited the most potent splenocytes-activating activity by increased cytokine production and NO release. It also suggested that the sulfate groups and molecular weight of polysaccharides are key factors to regulate the immunomodulatory activities.

Original language	English
Pages (from-to)	67-71
Number of pages	5
Journal	International Journal of Biological Macromolecules
Volume	46
Issue number	1
DOIs	https://doi.org/10.1016/j.ijbiomac.2009.10.007
State	Published - 1 Jan 2010
Externally published	Yes

Keywords

Chinese persimmon
Degree of substitution
Immunomodulatory activity
Splenocyte
Sulfated polysaccharides

Access to Document

10.1016/j.ijbiomac.2009.10.007

Cite this

@article{08282bff96444caab7995eb7916fd095,

title = "Sulfated modification and immunomodulatory activity of water-soluble polysaccharides derived from fresh Chinese persimmon fruit",

abstract = "In this study, three kinds of chemically sulfated polysaccharides (PFP-S) were derived from a water-soluble polysaccharide of persimmon fruit with chlorosulfonic acid-pyridine method. Relationship between the degree of substitution and immunomodulatory activity of PFP-S was examined with the splenocytes experiment. The results showed that the splenocytes-activating activity was significantly enhanced by PFP-S in all the groups compared with control group (P < 0.01). PFP-SII exhibited the most potent splenocytes-activating activity by increased cytokine production and NO release. It also suggested that the sulfate groups and molecular weight of polysaccharides are key factors to regulate the immunomodulatory activities.",

keywords = "Chinese persimmon, Degree of substitution, Immunomodulatory activity, Splenocyte, Sulfated polysaccharides",

author = "Yali Zhang and Xiaoyun Lu and Yuning Zhang and Liguo Qin and Jianbao Zhang",

year = "2010",

month = jan,

day = "1",

doi = "10.1016/j.ijbiomac.2009.10.007",

language = "英语",

volume = "46",

pages = "67--71",

journal = "International Journal of Biological Macromolecules",

issn = "0141-8130",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Sulfated modification and immunomodulatory activity of water-soluble polysaccharides derived from fresh Chinese persimmon fruit

AU - Zhang, Yali

AU - Lu, Xiaoyun

AU - Zhang, Yuning

AU - Qin, Liguo

AU - Zhang, Jianbao

PY - 2010/1/1

Y1 - 2010/1/1

N2 - In this study, three kinds of chemically sulfated polysaccharides (PFP-S) were derived from a water-soluble polysaccharide of persimmon fruit with chlorosulfonic acid-pyridine method. Relationship between the degree of substitution and immunomodulatory activity of PFP-S was examined with the splenocytes experiment. The results showed that the splenocytes-activating activity was significantly enhanced by PFP-S in all the groups compared with control group (P < 0.01). PFP-SII exhibited the most potent splenocytes-activating activity by increased cytokine production and NO release. It also suggested that the sulfate groups and molecular weight of polysaccharides are key factors to regulate the immunomodulatory activities.

AB - In this study, three kinds of chemically sulfated polysaccharides (PFP-S) were derived from a water-soluble polysaccharide of persimmon fruit with chlorosulfonic acid-pyridine method. Relationship between the degree of substitution and immunomodulatory activity of PFP-S was examined with the splenocytes experiment. The results showed that the splenocytes-activating activity was significantly enhanced by PFP-S in all the groups compared with control group (P < 0.01). PFP-SII exhibited the most potent splenocytes-activating activity by increased cytokine production and NO release. It also suggested that the sulfate groups and molecular weight of polysaccharides are key factors to regulate the immunomodulatory activities.

KW - Chinese persimmon

KW - Degree of substitution

KW - Immunomodulatory activity

KW - Splenocyte

KW - Sulfated polysaccharides

UR - https://www.scopus.com/pages/publications/71849099679

U2 - 10.1016/j.ijbiomac.2009.10.007

DO - 10.1016/j.ijbiomac.2009.10.007

M3 - 文章

C2 - 19828119

AN - SCOPUS:71849099679

SN - 0141-8130

VL - 46

SP - 67

EP - 71

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

IS - 1

ER -

Sulfated modification and immunomodulatory activity of water-soluble polysaccharides derived from fresh Chinese persimmon fruit

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this