Abstract
Objective: To study the formulation and preparation of nifedipine lipsomes (NP) and evaluate their quality. Methods: The liposomes were prepared by a film-ultrasonic technique. Served as quota with the entrapment ratio and appearance of liposomes, the optimal formation and preparation were selected by means of an orthogonal design test. The entrapment ratio of liposomes was studied by means of dialyzer. The size distribution of liposome was selected by photometry. The appearance of liposomes was observed by micrography. Results: The entrapment ratio of nifedipine liposomes was 89.02%. The result of electron micrography and the size distribution showed that the liposomes consisted of small spherical or similar to spherical small unilamellar vesicles (SUV), with 73.81% of particles in the liposomes smaller than 1.58 μm. Conclusion: The selected formulation and preparation of nifedipine lipsomes is practicable.
| Original language | English |
|---|---|
| Pages (from-to) | 414-416 |
| Number of pages | 3 |
| Journal | Journal of Xi'an Jiaotong University (Medical Sciences) |
| Volume | 23 |
| Issue number | 4 |
| State | Published - 2002 |
Keywords
- Liposome
- Nifedipine
- Quality evalation