Abstract
As a means of applying cold atmospheric plasma (CAP), plasma-activated solutions have received extensive attention for their excellent anticancer effects. However, previous studies have focused mainly on the local injection of plasma-activated solutions for cancer treatment while ignoring the anticancer effects of intraluminal plasma-activated solution perfusion. In this paper, the anticancer effects of flowing plasma-activated saline (PAS) on human bladder cancer cell lines (J82) were studied in vitro in a microfluidic system. It is noteworthy that flowing PAS can kill cancer cells more efficiently than PAS immersion. Further experimental results show that the anticancer effects of PAS on J82 cells in the microcavity are affected by plasma irradiation time, perfusion time and liquid flow rate. Our research suggests that PAS perfusion therapy can become a controllable alternative therapy pathway in the future clinical treatment of intracavitary tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 99-110 |
| Number of pages | 12 |
| Journal | Plasma Chemistry and Plasma Processing |
| Volume | 43 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2023 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cold atmospheric plasma
- Microfluidic system
- Perfusion therapy
- Plasma-activated saline
- Reactive oxygen species
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