Study on estimation of radiation dose using FTIR in mice thymus

Wen An Wu; Jian Sheng Wang; Jia Zhang; Fei Mo; Si Cen Wang; Su Na Zhou; Ming Xin Zhang; Yi Zhuang Xu; Jing Sen Shi; Jin Guang Wu

doi:10.3964/j.issn.1000-0593(2010)05-1189-03

Study on estimation of radiation dose using FTIR in mice thymus

Wen An Wu
, Jian Sheng Wang
, Jia Zhang
, Fei Mo
, Si Cen Wang
, Su Na Zhou
, Ming Xin Zhang
, Yi Zhuang Xu
, Jing Sen Shi
, Jin Guang Wu

Health Science Center

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Fourier transform infrared spectroscopy (FTIR) was applied to study the biochemical changes in the radiation damaged mouse thymus which increased with radiation dose and provided a new method for the estimation of the radiation dose of radiation damaged patients. The results demonstrated that with the dose increasing, the peak positions like 1550, 1400, 1400 and 1640 cm^-1 at the dose of 2, 3 and 5 Gy showed some difference, and there was obvious variance in the intensity: (1) The intensity ratio of 1085 to 1236 cm^-1 related to nucleic acid tended to decrease. (2) The intensity ratio of 1640/1550 decreased. (3) The intensity at 2958, 2925, 1460 and 1400 cm^-1 showed no significant difference. The results suggest that it may be possible for FTIR to become an effective method to estimate the radiation dose in clinic.

Original language	English
Pages (from-to)	1189-1191
Number of pages	3
Journal	Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis
Volume	30
Issue number	5
DOIs	https://doi.org/10.3964/j.issn.1000-0593(2010)05-1189-03
State	Published - May 2010

Keywords

FTIR
Radiation dose
Thymus tissue

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10.3964/j.issn.1000-0593(2010)05-1189-03

Cite this

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title = "Study on estimation of radiation dose using FTIR in mice thymus",

abstract = "Fourier transform infrared spectroscopy (FTIR) was applied to study the biochemical changes in the radiation damaged mouse thymus which increased with radiation dose and provided a new method for the estimation of the radiation dose of radiation damaged patients. The results demonstrated that with the dose increasing, the peak positions like 1550, 1400, 1400 and 1640 cm-1 at the dose of 2, 3 and 5 Gy showed some difference, and there was obvious variance in the intensity: (1) The intensity ratio of 1085 to 1236 cm-1 related to nucleic acid tended to decrease. (2) The intensity ratio of 1640/1550 decreased. (3) The intensity at 2958, 2925, 1460 and 1400 cm-1 showed no significant difference. The results suggest that it may be possible for FTIR to become an effective method to estimate the radiation dose in clinic.",

keywords = "FTIR, Radiation dose, Thymus tissue",

author = "Wu, \{Wen An\} and Wang, \{Jian Sheng\} and Jia Zhang and Fei Mo and Wang, \{Si Cen\} and Zhou, \{Su Na\} and Zhang, \{Ming Xin\} and Xu, \{Yi Zhuang\} and Shi, \{Jing Sen\} and Wu, \{Jin Guang\}",

year = "2010",

month = may,

doi = "10.3964/j.issn.1000-0593(2010)05-1189-03",

language = "英语",

volume = "30",

pages = "1189--1191",

journal = "Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis",

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TY - JOUR

T1 - Study on estimation of radiation dose using FTIR in mice thymus

AU - Wu, Wen An

AU - Wang, Jian Sheng

AU - Zhang, Jia

AU - Mo, Fei

AU - Wang, Si Cen

AU - Zhou, Su Na

AU - Zhang, Ming Xin

AU - Xu, Yi Zhuang

AU - Shi, Jing Sen

AU - Wu, Jin Guang

PY - 2010/5

Y1 - 2010/5

N2 - Fourier transform infrared spectroscopy (FTIR) was applied to study the biochemical changes in the radiation damaged mouse thymus which increased with radiation dose and provided a new method for the estimation of the radiation dose of radiation damaged patients. The results demonstrated that with the dose increasing, the peak positions like 1550, 1400, 1400 and 1640 cm-1 at the dose of 2, 3 and 5 Gy showed some difference, and there was obvious variance in the intensity: (1) The intensity ratio of 1085 to 1236 cm-1 related to nucleic acid tended to decrease. (2) The intensity ratio of 1640/1550 decreased. (3) The intensity at 2958, 2925, 1460 and 1400 cm-1 showed no significant difference. The results suggest that it may be possible for FTIR to become an effective method to estimate the radiation dose in clinic.

AB - Fourier transform infrared spectroscopy (FTIR) was applied to study the biochemical changes in the radiation damaged mouse thymus which increased with radiation dose and provided a new method for the estimation of the radiation dose of radiation damaged patients. The results demonstrated that with the dose increasing, the peak positions like 1550, 1400, 1400 and 1640 cm-1 at the dose of 2, 3 and 5 Gy showed some difference, and there was obvious variance in the intensity: (1) The intensity ratio of 1085 to 1236 cm-1 related to nucleic acid tended to decrease. (2) The intensity ratio of 1640/1550 decreased. (3) The intensity at 2958, 2925, 1460 and 1400 cm-1 showed no significant difference. The results suggest that it may be possible for FTIR to become an effective method to estimate the radiation dose in clinic.

KW - FTIR

KW - Radiation dose

KW - Thymus tissue

UR - https://www.scopus.com/pages/publications/77952798637

U2 - 10.3964/j.issn.1000-0593(2010)05-1189-03

DO - 10.3964/j.issn.1000-0593(2010)05-1189-03

M3 - 文章

C2 - 20672598

AN - SCOPUS:77952798637

SN - 1000-0593

VL - 30

SP - 1189

EP - 1191

JO - Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis

JF - Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis

IS - 5

ER -

Study on estimation of radiation dose using FTIR in mice thymus

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