Streamlined Electrochemical Dihalogenation (F, Cl, and Br) of gem-Difluoroalkenes Using Hydrogen Halides as Reagents

We established a straightforward electrochemical dihalogenation (F, Cl, and Br) process for gem-difluoroalkenes. This reaction exhibits a broad functional group tolerance and has been effectively utilized in the construction of complex molecules. The subsequent synthetic transformations of the products have highlighted the adaptable nature of the dihalogenated compounds, demonstrating their potential application in drug discovery and the investigation of innovative materials. The effective utilization of the dihalogenated product for ¹⁸F-labeling represents a novel approach in generating highly potent ¹⁸F-labeled tracers.