Abstract
The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.
| Original language | English |
|---|---|
| Pages (from-to) | 359-363 |
| Number of pages | 5 |
| Journal | Ai zheng = Aizheng = Chinese journal of cancer |
| Volume | 31 |
| Issue number | 8 |
| DOIs | |
| State | Published - 14 Jun 2012 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- DNA damage response
- DNA repair
- PARP inhibitors
- Synthetic lethality
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