Star Poly(β-amino esters) Obtained from the Combination of Linear Poly(β-amino esters) and Polyethylenimine

Xiaobei Huang; Dezhong Zhou; Ming Zeng; Fatma Alshehri; Xiaolin Li; Jonathan O'Keeffe-Ahern; Yongsheng Gao; Luca Pierucci; Udo Greiser; Guangfu Yin; Wenxin Wang

doi:10.1021/acsmacrolett.7b00319

Star Poly(β-amino esters) Obtained from the Combination of Linear Poly(β-amino esters) and Polyethylenimine

Xiaobei Huang
, Dezhong Zhou
, Ming Zeng
, Fatma Alshehri
, Xiaolin Li
, Jonathan O'Keeffe-Ahern
, Yongsheng Gao
, Luca Pierucci
, Udo Greiser
, Guangfu Yin
, Wenxin Wang

Sichuan University
University College Dublin

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Composed of a three-dimensional structure with a central core and multiple radiating linear "arms", star polymers represent a significant type of branched macromolecular architectures. Due to the spatially defined core-shell-periphery architecture, star polymers have demonstrated their superiority in a variety of biomedical applications such as drug/gene delivery, molecular imaging, antibacterial agents, and so on. In this paper, we report the successful synthesis of a new type of star-shape poly(β-amino esters) with low molecular weight PEI as core and linear PAE (LPAE) as arms. This new star-PAE exhibits low cytotoxicity and high gene transfection efficacy. Star-PAE achieved between 264-fold and 14781-fold higher gene transfection efficiency of primary rat adipose derived mesenchymal stem cells in comparison with studies performed with the individual PEI and LPAE, respectively. The results suggest that star-PAE is a promising nonviral gene delivery vector.

Original language	English
Pages (from-to)	575-579
Number of pages	5
Journal	ACS Macro Letters
Volume	6
Issue number	6
DOIs	https://doi.org/10.1021/acsmacrolett.7b00319
State	Published - 20 Jun 2017
Externally published	Yes

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10.1021/acsmacrolett.7b00319

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title = "Star Poly(β-amino esters) Obtained from the Combination of Linear Poly(β-amino esters) and Polyethylenimine",

abstract = "Composed of a three-dimensional structure with a central core and multiple radiating linear {"}arms{"}, star polymers represent a significant type of branched macromolecular architectures. Due to the spatially defined core-shell-periphery architecture, star polymers have demonstrated their superiority in a variety of biomedical applications such as drug/gene delivery, molecular imaging, antibacterial agents, and so on. In this paper, we report the successful synthesis of a new type of star-shape poly(β-amino esters) with low molecular weight PEI as core and linear PAE (LPAE) as arms. This new star-PAE exhibits low cytotoxicity and high gene transfection efficacy. Star-PAE achieved between 264-fold and 14781-fold higher gene transfection efficiency of primary rat adipose derived mesenchymal stem cells in comparison with studies performed with the individual PEI and LPAE, respectively. The results suggest that star-PAE is a promising nonviral gene delivery vector.",

author = "Xiaobei Huang and Dezhong Zhou and Ming Zeng and Fatma Alshehri and Xiaolin Li and Jonathan O'Keeffe-Ahern and Yongsheng Gao and Luca Pierucci and Udo Greiser and Guangfu Yin and Wenxin Wang",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

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doi = "10.1021/acsmacrolett.7b00319",

language = "英语",

volume = "6",

pages = "575--579",

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TY - JOUR

T1 - Star Poly(β-amino esters) Obtained from the Combination of Linear Poly(β-amino esters) and Polyethylenimine

AU - Huang, Xiaobei

AU - Zhou, Dezhong

AU - Zeng, Ming

AU - Alshehri, Fatma

AU - Li, Xiaolin

AU - O'Keeffe-Ahern, Jonathan

AU - Gao, Yongsheng

AU - Pierucci, Luca

AU - Greiser, Udo

AU - Yin, Guangfu

AU - Wang, Wenxin

PY - 2017/6/20

Y1 - 2017/6/20

N2 - Composed of a three-dimensional structure with a central core and multiple radiating linear "arms", star polymers represent a significant type of branched macromolecular architectures. Due to the spatially defined core-shell-periphery architecture, star polymers have demonstrated their superiority in a variety of biomedical applications such as drug/gene delivery, molecular imaging, antibacterial agents, and so on. In this paper, we report the successful synthesis of a new type of star-shape poly(β-amino esters) with low molecular weight PEI as core and linear PAE (LPAE) as arms. This new star-PAE exhibits low cytotoxicity and high gene transfection efficacy. Star-PAE achieved between 264-fold and 14781-fold higher gene transfection efficiency of primary rat adipose derived mesenchymal stem cells in comparison with studies performed with the individual PEI and LPAE, respectively. The results suggest that star-PAE is a promising nonviral gene delivery vector.

AB - Composed of a three-dimensional structure with a central core and multiple radiating linear "arms", star polymers represent a significant type of branched macromolecular architectures. Due to the spatially defined core-shell-periphery architecture, star polymers have demonstrated their superiority in a variety of biomedical applications such as drug/gene delivery, molecular imaging, antibacterial agents, and so on. In this paper, we report the successful synthesis of a new type of star-shape poly(β-amino esters) with low molecular weight PEI as core and linear PAE (LPAE) as arms. This new star-PAE exhibits low cytotoxicity and high gene transfection efficacy. Star-PAE achieved between 264-fold and 14781-fold higher gene transfection efficiency of primary rat adipose derived mesenchymal stem cells in comparison with studies performed with the individual PEI and LPAE, respectively. The results suggest that star-PAE is a promising nonviral gene delivery vector.

UR - https://www.scopus.com/pages/publications/85021131605

U2 - 10.1021/acsmacrolett.7b00319

DO - 10.1021/acsmacrolett.7b00319

M3 - 文章

C2 - 35650840

AN - SCOPUS:85021131605

SN - 2161-1653

VL - 6

SP - 575

EP - 579

JO - ACS Macro Letters

JF - ACS Macro Letters

IS - 6

ER -

Star Poly(β-amino esters) Obtained from the Combination of Linear Poly(β-amino esters) and Polyethylenimine

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