Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people

Hengxin Li; Jun Chen; Rui Zhi Zhang; Ran Xu; Zhe Zhang; Le Ren; Qi Yang; Yumei Tian; Daxu Li

doi:10.18632/oncotarget.19669

Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people

Hengxin Li
, Jun Chen
, Rui Zhi Zhang
, Ran Xu
, Zhe Zhang
, Le Ren
, Qi Yang
, Yumei Tian
, Daxu Li

Xi'an Center for Chronic and Non-communicable Disease Control and Prevention
Ankang Central Hospital
Xi'an Jiaotong University
The First Affiliated Hospital of Xi’an Jiaotong University
Shantou University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Single nucleotide polymorphisms (SNPs) in ZNF208 may be associated with susceptibility to Hepatitis B virus (HBV). In the current study, we analyzed the association between ZNF208 SNPs and risk of HBV in 242 HBV patients and 300 healthy subjects from the Xi'an area of Chinese Han Population. Of the five SNPs examined, rs2188971 (OR: 1.36, 95% CI: 1.04-1.76, P = 0.022), rs8103163 (OR: 1.40, 95% CI: 1.08-1.82, P = 0.010) and rs7248488 (OR: 1.38, 95% CI: 1.07-1.79, P = 0.014) were correlated with HBV susceptibility based on Chi-square tests. After the P-values were adjusted by Bonferroni correction, there only rs8103163 (P = 0.050) was slightly with increased HBV risk. Additionally, haplotype A_rs2188972T_rs2188971A_rs8103163A_rs7248488 (OR = 1.42; 95% C I, 1.10-1.85; P = 0.008) was found to increase susceptibility of suffering from HBV. These findings suggest that ZNF208 polymorphisms may contribute to the development of HBV.

Original language	English
Pages (from-to)	112451-112459
Number of pages	9
Journal	Oncotarget
Volume	8
Issue number	68
DOIs	https://doi.org/10.18632/oncotarget.19669
State	Published - 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chinese Han population
HBV
SNPs
Susceptibility
ZNF208

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10.18632/oncotarget.19669

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@article{36d5cce2e5604d3087e1d5b50f6fbaed,

title = "Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people",

abstract = "Single nucleotide polymorphisms (SNPs) in ZNF208 may be associated with susceptibility to Hepatitis B virus (HBV). In the current study, we analyzed the association between ZNF208 SNPs and risk of HBV in 242 HBV patients and 300 healthy subjects from the Xi'an area of Chinese Han Population. Of the five SNPs examined, rs2188971 (OR: 1.36, 95\% CI: 1.04-1.76, P = 0.022), rs8103163 (OR: 1.40, 95\% CI: 1.08-1.82, P = 0.010) and rs7248488 (OR: 1.38, 95\% CI: 1.07-1.79, P = 0.014) were correlated with HBV susceptibility based on Chi-square tests. After the P-values were adjusted by Bonferroni correction, there only rs8103163 (P = 0.050) was slightly with increased HBV risk. Additionally, haplotype Ars2188972Trs2188971Ars8103163Ars7248488 (OR = 1.42; 95\% C I, 1.10-1.85; P = 0.008) was found to increase susceptibility of suffering from HBV. These findings suggest that ZNF208 polymorphisms may contribute to the development of HBV.",

keywords = "Chinese Han population, HBV, SNPs, Susceptibility, ZNF208",

author = "Hengxin Li and Jun Chen and Zhang, \{Rui Zhi\} and Ran Xu and Zhe Zhang and Le Ren and Qi Yang and Yumei Tian and Daxu Li",

note = "Publisher Copyright: {\textcopyright} Li et al.",

year = "2017",

doi = "10.18632/oncotarget.19669",

language = "英语",

volume = "8",

pages = "112451--112459",

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TY - JOUR

T1 - Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people

AU - Li, Hengxin

AU - Chen, Jun

AU - Zhang, Rui Zhi

AU - Xu, Ran

AU - Zhang, Zhe

AU - Ren, Le

AU - Yang, Qi

AU - Tian, Yumei

AU - Li, Daxu

N1 - Publisher Copyright: © Li et al.

PY - 2017

Y1 - 2017

N2 - Single nucleotide polymorphisms (SNPs) in ZNF208 may be associated with susceptibility to Hepatitis B virus (HBV). In the current study, we analyzed the association between ZNF208 SNPs and risk of HBV in 242 HBV patients and 300 healthy subjects from the Xi'an area of Chinese Han Population. Of the five SNPs examined, rs2188971 (OR: 1.36, 95% CI: 1.04-1.76, P = 0.022), rs8103163 (OR: 1.40, 95% CI: 1.08-1.82, P = 0.010) and rs7248488 (OR: 1.38, 95% CI: 1.07-1.79, P = 0.014) were correlated with HBV susceptibility based on Chi-square tests. After the P-values were adjusted by Bonferroni correction, there only rs8103163 (P = 0.050) was slightly with increased HBV risk. Additionally, haplotype Ars2188972Trs2188971Ars8103163Ars7248488 (OR = 1.42; 95% C I, 1.10-1.85; P = 0.008) was found to increase susceptibility of suffering from HBV. These findings suggest that ZNF208 polymorphisms may contribute to the development of HBV.

AB - Single nucleotide polymorphisms (SNPs) in ZNF208 may be associated with susceptibility to Hepatitis B virus (HBV). In the current study, we analyzed the association between ZNF208 SNPs and risk of HBV in 242 HBV patients and 300 healthy subjects from the Xi'an area of Chinese Han Population. Of the five SNPs examined, rs2188971 (OR: 1.36, 95% CI: 1.04-1.76, P = 0.022), rs8103163 (OR: 1.40, 95% CI: 1.08-1.82, P = 0.010) and rs7248488 (OR: 1.38, 95% CI: 1.07-1.79, P = 0.014) were correlated with HBV susceptibility based on Chi-square tests. After the P-values were adjusted by Bonferroni correction, there only rs8103163 (P = 0.050) was slightly with increased HBV risk. Additionally, haplotype Ars2188972Trs2188971Ars8103163Ars7248488 (OR = 1.42; 95% C I, 1.10-1.85; P = 0.008) was found to increase susceptibility of suffering from HBV. These findings suggest that ZNF208 polymorphisms may contribute to the development of HBV.

KW - Chinese Han population

KW - HBV

KW - SNPs

KW - Susceptibility

KW - ZNF208

UR - https://www.scopus.com/pages/publications/85038808278

U2 - 10.18632/oncotarget.19669

DO - 10.18632/oncotarget.19669

M3 - 文章

C2 - 29348838

AN - SCOPUS:85038808278

SN - 1949-2553

VL - 8

SP - 112451

EP - 112459

JO - Oncotarget

JF - Oncotarget

IS - 68

ER -

Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people

Abstract

UN SDGs

Keywords

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