TY - GEN
T1 - Simulation and design of a cell-based digital microfluidic chip for continuous monitoring of acute toxic chemicals
AU - Dong, Tao
AU - Molino, Matteo
AU - Demarchi, Danilo
PY - 2013
Y1 - 2013
N2 - In this study, a lab-on-chip (LOC) system is designed for the cell sensors to provide a high-efficient continuous analysis platform of acute toxicants in water environment. The chip is composed of three domains, including counter-flow micromixers, a T-junction droplet generator and time delay channels (TD-Cs). Water sample and bioluminescent bacterium Vibrio Fischeri (VF) are imported into the micromixers before that the droplet generator encapsulates them inside aqueous droplets separated by air. Air flow is the disperse medium, which can guarantee sufficient oxygen supply for the cells in droplets. The system shows high reliability and stability through numerical and experimental investigations.
AB - In this study, a lab-on-chip (LOC) system is designed for the cell sensors to provide a high-efficient continuous analysis platform of acute toxicants in water environment. The chip is composed of three domains, including counter-flow micromixers, a T-junction droplet generator and time delay channels (TD-Cs). Water sample and bioluminescent bacterium Vibrio Fischeri (VF) are imported into the micromixers before that the droplet generator encapsulates them inside aqueous droplets separated by air. Air flow is the disperse medium, which can guarantee sufficient oxygen supply for the cells in droplets. The system shows high reliability and stability through numerical and experimental investigations.
KW - Cell-based sensor
KW - Digital microfluidic
KW - Micro-mixer
KW - Two-phase flow simulation
UR - https://www.scopus.com/pages/publications/84883019142
U2 - 10.4028/www.scientific.net/AMM.336-338.523
DO - 10.4028/www.scientific.net/AMM.336-338.523
M3 - 会议稿件
AN - SCOPUS:84883019142
SN - 9783037857519
T3 - Applied Mechanics and Materials
SP - 523
EP - 527
BT - Industrial Instrumentation and Control Systems II
T2 - 2013 2nd International Conference on Measurement, Instrumentation and Automation, ICMIA 2013
Y2 - 23 April 2013 through 24 April 2013
ER -
