TY - JOUR
T1 - Sex specific effect of gut microbiota on the risk of psychiatric disorders
T2 - A Mendelian randomisation study and PRS analysis using UK Biobank cohort
AU - Qi, Xin
AU - Guan, Fanglin
AU - Cheng, Shiqiang
AU - Wen, Yan
AU - Liu, Li
AU - Ma, Mei
AU - Cheng, Bolun
AU - Liang, Chujun
AU - Zhang, Lu
AU - Liang, Xiao
AU - Li, Ping
AU - Chu, Xiaomeng
AU - Ye, Jing
AU - Yao, Yao
AU - Zhang, Feng
N1 - Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Objective: The relationships between gut microbiota and brain-related diseases/traits remains not fully understood. Method: A two-stage study was performed to investigate the relationships between gut microbiota and brain-related diseases/traits, and evaluate the potential sex specific effects of gut microbiota. In discovery stage, we systematically scanned the relationships between 515 brain-related diseases/traits and gut microbiota through two-sample Mendelian randomisation analysis. Using ∼500,000 individuals derived from the UK Biobank, polygenetic risk scoring (PRS) analysis was performed to validate the associations detected in discovery stage. To evaluate the potential sex-specific effect of gut microbiota on brain-related disorders, PRS analysis was conducted in female and male, respectively. Results: After systematically scanning diseases or traits, 41 of the 515 brain-related diseases/traits were identified to be associated with gut microbiota, such as Neuroticism score (P2-MR = 0.0018), worrier/anxious feelings (P2-MR = 0.0013), Suffer from ‘nerves’ (P2-MR = 0.0062) and Nervous feelings (P2-MR = 0.0158). 5 of 41 brain-related diseases or traits were successfully validated in UK Biobank, such as Neuroticism score (PUK = 0.0024, PUK-female = 0.0063, PUK-male = 0.1142), Nervous feelings (PUK = 0.0043, PUK-female = 0.0115, PUK-male = 0.1670) and Worrier/anxious feelings (PUK = 0.0166, PUK-female = 0.0196, PUK-male = 0.2930). Conclusion: Our results suggest that gut microbiota contributed more to brain-related diseases or traits in females than in males.Key points A two-stage study was performed to investigate the relationships between gut microbiota and brain-related diseases/traits. Using the individuals derived from the UK Biobank, polygenetic risk scoring analysis was performed to validate the associations detected in the discovery stage. Our results suggest that gut microbiota contributed more to brain-related diseases or traits in females than in males.
AB - Objective: The relationships between gut microbiota and brain-related diseases/traits remains not fully understood. Method: A two-stage study was performed to investigate the relationships between gut microbiota and brain-related diseases/traits, and evaluate the potential sex specific effects of gut microbiota. In discovery stage, we systematically scanned the relationships between 515 brain-related diseases/traits and gut microbiota through two-sample Mendelian randomisation analysis. Using ∼500,000 individuals derived from the UK Biobank, polygenetic risk scoring (PRS) analysis was performed to validate the associations detected in discovery stage. To evaluate the potential sex-specific effect of gut microbiota on brain-related disorders, PRS analysis was conducted in female and male, respectively. Results: After systematically scanning diseases or traits, 41 of the 515 brain-related diseases/traits were identified to be associated with gut microbiota, such as Neuroticism score (P2-MR = 0.0018), worrier/anxious feelings (P2-MR = 0.0013), Suffer from ‘nerves’ (P2-MR = 0.0062) and Nervous feelings (P2-MR = 0.0158). 5 of 41 brain-related diseases or traits were successfully validated in UK Biobank, such as Neuroticism score (PUK = 0.0024, PUK-female = 0.0063, PUK-male = 0.1142), Nervous feelings (PUK = 0.0043, PUK-female = 0.0115, PUK-male = 0.1670) and Worrier/anxious feelings (PUK = 0.0166, PUK-female = 0.0196, PUK-male = 0.2930). Conclusion: Our results suggest that gut microbiota contributed more to brain-related diseases or traits in females than in males.Key points A two-stage study was performed to investigate the relationships between gut microbiota and brain-related diseases/traits. Using the individuals derived from the UK Biobank, polygenetic risk scoring analysis was performed to validate the associations detected in the discovery stage. Our results suggest that gut microbiota contributed more to brain-related diseases or traits in females than in males.
KW - brain
KW - Gut microbiota
KW - neurological disorders
KW - psychiatric disorders
KW - sex specific
UR - https://www.scopus.com/pages/publications/85104254593
U2 - 10.1080/15622975.2021.1878428
DO - 10.1080/15622975.2021.1878428
M3 - 文献综述
C2 - 33834943
AN - SCOPUS:85104254593
SN - 1562-2975
VL - 22
SP - 495
EP - 504
JO - World Journal of Biological Psychiatry
JF - World Journal of Biological Psychiatry
IS - 7
ER -
