Serum reference interval of ARCHITECT alpha-fetoprotein in healthy Chinese Han adults: Sub-analysis of a prospective multi-center study

Cunling Yan; Jia Yang; Lianhua Wei; Jian Hu; Jiaqi Song; Xiaoqin Wang; Ruilin Han; Ying Huang; Wei Zhang; Andrew Soh; Agim Beshiri; Zhuping Fan; Yijie Zheng; Wei Chen

doi:10.1016/j.clinbiochem.2017.11.002

Serum reference interval of ARCHITECT alpha-fetoprotein in healthy Chinese Han adults: Sub-analysis of a prospective multi-center study

Cunling Yan
, Jia Yang
, Lianhua Wei
, Jian Hu
, Jiaqi Song
, Xiaoqin Wang
, Ruilin Han
, Ying Huang
, Wei Zhang
, Andrew Soh
, Agim Beshiri
, Zhuping Fan
, Yijie Zheng
, Wei Chen

Health Science Center

Peking University
Provincial People's Hospital
Provincial People's Hospital
Xi'an Jiaotong University
Naval Medical University
Abbott Laboratories
Abbott Diagnostics
Shanghai Jiao Tong University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Objectives Alpha-fetoprotein (AFP) has been widely used in clinical practice for decades. However, large-scale survey of serum reference interval for ARCHITECT AFP is still absent in Chinese population. This study aimed to measure serum AFP levels in healthy Chinese Han subjects, which is a sub-analysis of an ongoing prospective, cross-sectional, multi-center study (ClinicalTrials.gov Identifier: NCT03047603). Methods This analysis included a total of 530 participants (41.43 ± 12.14 years of age on average, 48.49% males), enrolled from 5 regional centers. Serum AFP level was measured by ARCHITECT immunoassay. Statistical analysis was performed using SAS 9.4 and R software. Results AFP distribution did not show significant correlation with age or sex. The overall median and interquartile range of AFP was 2.87 (2.09, 3.83) ng/mL. AFP level did not show a trend of increasing with age. The new reference interval was 2.0–7.07 ng/mL (LOQ– 97.5th percentiles). Conclusions The reference interval for ARCHITECT AFP is updated with the data of adequate number of healthy Han adults. This new reference interval is more practical and applicable in Chinese adults.

Original language	English
Pages (from-to)	164-166
Number of pages	3
Journal	Clinical Biochemistry
Volume	52
DOIs	https://doi.org/10.1016/j.clinbiochem.2017.11.002
State	Published - Feb 2018

Keywords

Alpha-fetoprotein
Hepatocellular carcinoma
Reference interval

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10.1016/j.clinbiochem.2017.11.002

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Yan, C., Yang, J., Wei, L., Hu, J., Song, J., Wang, X., Han, R., Huang, Y., Zhang, W., Soh, A., Beshiri, A., Fan, Z., Zheng, Y., & Chen, W. (2018). Serum reference interval of ARCHITECT alpha-fetoprotein in healthy Chinese Han adults: Sub-analysis of a prospective multi-center study. Clinical Biochemistry, 52, 164-166. https://doi.org/10.1016/j.clinbiochem.2017.11.002

@article{355915fe8cff497d9372566c8d0b955d,

title = "Serum reference interval of ARCHITECT alpha-fetoprotein in healthy Chinese Han adults: Sub-analysis of a prospective multi-center study",

abstract = "Objectives Alpha-fetoprotein (AFP) has been widely used in clinical practice for decades. However, large-scale survey of serum reference interval for ARCHITECT AFP is still absent in Chinese population. This study aimed to measure serum AFP levels in healthy Chinese Han subjects, which is a sub-analysis of an ongoing prospective, cross-sectional, multi-center study (ClinicalTrials.gov Identifier: NCT03047603). Methods This analysis included a total of 530 participants (41.43 ± 12.14 years of age on average, 48.49\% males), enrolled from 5 regional centers. Serum AFP level was measured by ARCHITECT immunoassay. Statistical analysis was performed using SAS 9.4 and R software. Results AFP distribution did not show significant correlation with age or sex. The overall median and interquartile range of AFP was 2.87 (2.09, 3.83) ng/mL. AFP level did not show a trend of increasing with age. The new reference interval was 2.0{\textendash}7.07 ng/mL (LOQ{\textendash} 97.5th percentiles). Conclusions The reference interval for ARCHITECT AFP is updated with the data of adequate number of healthy Han adults. This new reference interval is more practical and applicable in Chinese adults.",

keywords = "Alpha-fetoprotein, Hepatocellular carcinoma, Reference interval",

author = "Cunling Yan and Jia Yang and Lianhua Wei and Jian Hu and Jiaqi Song and Xiaoqin Wang and Ruilin Han and Ying Huang and Wei Zhang and Andrew Soh and Agim Beshiri and Zhuping Fan and Yijie Zheng and Wei Chen",

note = "Publisher Copyright: {\textcopyright} 2017 The Canadian Society of Clinical Chemists",

year = "2018",

month = feb,

doi = "10.1016/j.clinbiochem.2017.11.002",

language = "英语",

volume = "52",

pages = "164--166",

journal = "Clinical Biochemistry",

issn = "0009-9120",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Serum reference interval of ARCHITECT alpha-fetoprotein in healthy Chinese Han adults

T2 - Sub-analysis of a prospective multi-center study

AU - Yan, Cunling

AU - Yang, Jia

AU - Wei, Lianhua

AU - Hu, Jian

AU - Song, Jiaqi

AU - Wang, Xiaoqin

AU - Han, Ruilin

AU - Huang, Ying

AU - Zhang, Wei

AU - Soh, Andrew

AU - Beshiri, Agim

AU - Fan, Zhuping

AU - Zheng, Yijie

AU - Chen, Wei

PY - 2018/2

Y1 - 2018/2

N2 - Objectives Alpha-fetoprotein (AFP) has been widely used in clinical practice for decades. However, large-scale survey of serum reference interval for ARCHITECT AFP is still absent in Chinese population. This study aimed to measure serum AFP levels in healthy Chinese Han subjects, which is a sub-analysis of an ongoing prospective, cross-sectional, multi-center study (ClinicalTrials.gov Identifier: NCT03047603). Methods This analysis included a total of 530 participants (41.43 ± 12.14 years of age on average, 48.49% males), enrolled from 5 regional centers. Serum AFP level was measured by ARCHITECT immunoassay. Statistical analysis was performed using SAS 9.4 and R software. Results AFP distribution did not show significant correlation with age or sex. The overall median and interquartile range of AFP was 2.87 (2.09, 3.83) ng/mL. AFP level did not show a trend of increasing with age. The new reference interval was 2.0–7.07 ng/mL (LOQ– 97.5th percentiles). Conclusions The reference interval for ARCHITECT AFP is updated with the data of adequate number of healthy Han adults. This new reference interval is more practical and applicable in Chinese adults.

AB - Objectives Alpha-fetoprotein (AFP) has been widely used in clinical practice for decades. However, large-scale survey of serum reference interval for ARCHITECT AFP is still absent in Chinese population. This study aimed to measure serum AFP levels in healthy Chinese Han subjects, which is a sub-analysis of an ongoing prospective, cross-sectional, multi-center study (ClinicalTrials.gov Identifier: NCT03047603). Methods This analysis included a total of 530 participants (41.43 ± 12.14 years of age on average, 48.49% males), enrolled from 5 regional centers. Serum AFP level was measured by ARCHITECT immunoassay. Statistical analysis was performed using SAS 9.4 and R software. Results AFP distribution did not show significant correlation with age or sex. The overall median and interquartile range of AFP was 2.87 (2.09, 3.83) ng/mL. AFP level did not show a trend of increasing with age. The new reference interval was 2.0–7.07 ng/mL (LOQ– 97.5th percentiles). Conclusions The reference interval for ARCHITECT AFP is updated with the data of adequate number of healthy Han adults. This new reference interval is more practical and applicable in Chinese adults.

KW - Alpha-fetoprotein

KW - Hepatocellular carcinoma

KW - Reference interval

UR - https://www.scopus.com/pages/publications/85034448475

U2 - 10.1016/j.clinbiochem.2017.11.002

DO - 10.1016/j.clinbiochem.2017.11.002

M3 - 文章

C2 - 29129627

AN - SCOPUS:85034448475

SN - 0009-9120

VL - 52

SP - 164

EP - 166

JO - Clinical Biochemistry

JF - Clinical Biochemistry

ER -

Serum reference interval of ARCHITECT alpha-fetoprotein in healthy Chinese Han adults: Sub-analysis of a prospective multi-center study

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Keywords

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