TY - JOUR
T1 - Serum CETP concentration is not associated with measures of body fat
T2 - The NEO study
AU - Blauw, Lisanne L.
AU - de Mutsert, Renée
AU - Lamb, Hildo J.
AU - de Roos, Albert
AU - Rosendaal, Frits R.
AU - Jukema, J. Wouter
AU - Wang, Yanan
AU - van Dijk, Ko Willems
AU - Rensen, Patrick C.N.
N1 - Publisher Copyright:
© 2016 Elsevier Ireland Ltd.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Introduction: Adipose tissue has been postulated to contribute substantially to the serum cholesteryl ester transfer protein (CETP) pool. However, in a recent large cohort study waist circumference was not associated with plasma CETP. The aim of the present study was to further examine associations of accurate measures of body fat and body fat distribution with serum CETP concentration. Methods: In this cross-sectional analysis of the Netherlands Epidemiology of Obesity study, we examined in 6606 participants (aged 45-65 years) the associations of total body fat, body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), abdominal subcutaneous (aSAT) and visceral adipose tissue (VAT) assessed with magnetic resonance imaging (n = 2547) and total and trunk fat mass assessed with dual-energy X-ray absorptiometry (n = 909) with serum CETP concentration. Regression models were adjusted for age, ethnicity, sex, dietary intake of fat and cholesterol, physical activity, smoking and menopausal status. Results: Mean (SD) age was 56 (6) years and BMI 26.3 (4.4) kg/m2, 56% were women. Mean serum CETP concentration was 2.47 μg/mL. The difference in serum CETP was 0.02 μg/mL (95%CI: -0.01, 0.05) per SD total body fat (8.7%), and 0.02 μg/mL (0.00, 0.04) per SD BMI (4.4 kg/m2). Similar associations around the null were observed for waist circumference, WHR, aSAT, VAT, total and trunk fat mass. Conclusion: In this population-based study, there was no evidence for clinically relevant associations between several measures of body fat and serum CETP concentration. This finding implies that adipose tissue does not contribute to the CETP pool in serum.
AB - Introduction: Adipose tissue has been postulated to contribute substantially to the serum cholesteryl ester transfer protein (CETP) pool. However, in a recent large cohort study waist circumference was not associated with plasma CETP. The aim of the present study was to further examine associations of accurate measures of body fat and body fat distribution with serum CETP concentration. Methods: In this cross-sectional analysis of the Netherlands Epidemiology of Obesity study, we examined in 6606 participants (aged 45-65 years) the associations of total body fat, body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), abdominal subcutaneous (aSAT) and visceral adipose tissue (VAT) assessed with magnetic resonance imaging (n = 2547) and total and trunk fat mass assessed with dual-energy X-ray absorptiometry (n = 909) with serum CETP concentration. Regression models were adjusted for age, ethnicity, sex, dietary intake of fat and cholesterol, physical activity, smoking and menopausal status. Results: Mean (SD) age was 56 (6) years and BMI 26.3 (4.4) kg/m2, 56% were women. Mean serum CETP concentration was 2.47 μg/mL. The difference in serum CETP was 0.02 μg/mL (95%CI: -0.01, 0.05) per SD total body fat (8.7%), and 0.02 μg/mL (0.00, 0.04) per SD BMI (4.4 kg/m2). Similar associations around the null were observed for waist circumference, WHR, aSAT, VAT, total and trunk fat mass. Conclusion: In this population-based study, there was no evidence for clinically relevant associations between several measures of body fat and serum CETP concentration. This finding implies that adipose tissue does not contribute to the CETP pool in serum.
KW - Body fat
KW - Body fat distribution
KW - Cholesteryl ester transfer protein
KW - Subcutaneous adipose tissue
KW - Visceral adipose tissue
UR - https://www.scopus.com/pages/publications/84955288342
U2 - 10.1016/j.atherosclerosis.2016.01.031
DO - 10.1016/j.atherosclerosis.2016.01.031
M3 - 文章
C2 - 26820801
AN - SCOPUS:84955288342
SN - 0021-9150
VL - 246
SP - 267
EP - 273
JO - Atherosclerosis
JF - Atherosclerosis
ER -
