TY - JOUR
T1 - Seroprevalence and spatial distribution of immunoglobulin (IgG) antibodies against human parvovirus B19 in voluntary blood donors from Shaanxi Province, China
T2 - A cross-sectional study
AU - Zhao, Boya
AU - Chu, Xiaoyue
AU - Chen, Fangyao
AU - Chen, Hailong
AU - Jin, Yuqi
AU - Zhang, Dan
AU - Pan, Yongheng
AU - Cao, Wei
AU - Wang, Jin
AU - Gong, Hanshi
AU - Chen, Ping
AU - Sun, Xiaomin
AU - Pan, Deng
AU - Ma, Chaofeng
N1 - Publisher Copyright:
© The Author(s) 2026. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
PY - 2026/1/1
Y1 - 2026/1/1
N2 - Objective: Since late 2023, human parvovirus B19 (B19V) has been erupting continuously in multiple countries. Although transfusion-transmitted infections remain rarely documented, donations harbouring high-titre, undetected virus could still breach current pathogen-reduction processes and pose a potential threat to the safety of blood and blood products. To evaluate local risk, this study first determines the immunoglobulin G (IgG) seroprevalence of B19V and its geographic distribution among voluntary blood donors in Shaanxi Province. Methods: In this cross-sectional study, from August to December 2024, an enzyme-linked immunosorbent assay was used to detect the IgG antibody against B19V in sampled batches of qualified blood samples from five municipal central blood stations in Shaanxi Province, and the distribution characteristics of samples were analysed from multiple perspectives. Results: In Shaanxi Province, the B19V IgG antibody positivity rate was 24.95% (533 out of 2136), and increased with age (p < 0.001). Positive cases showed significant spatial clustering (p < 0.001), with a higher number of positive cases in Central Shaanxi and a lower number of positive cases in Northern and Southern Shaanxi. The infection risks were significantly different between northern and southern regions (odds ratio [OR]: 0.592, 95% confidence interval [CI]: 0.448–0.782, p < 0.001). Compared to type A blood, individuals with type B blood have a lower risk of previous infection (OR: 0.718, 95% CI: 0.549–0.940, p < 0.05). Conclusions: The previous infection rate of B19V is high among blood donors in Shaanxi Province, influenced by age, blood type, and geography. Given that B19V screening is not yet part of routine donor testing in China, we recommend that blood or blood components intended for immunocompromised, high-risk recipients be tested for B19V before transfusion, so as to reduce the risk of transfusion-transmitted infection in an economical and efficient manner. Future studies should focus on the long-term dynamics of B19V infection and the effectiveness of screening programs in reducing transmission risks.
AB - Objective: Since late 2023, human parvovirus B19 (B19V) has been erupting continuously in multiple countries. Although transfusion-transmitted infections remain rarely documented, donations harbouring high-titre, undetected virus could still breach current pathogen-reduction processes and pose a potential threat to the safety of blood and blood products. To evaluate local risk, this study first determines the immunoglobulin G (IgG) seroprevalence of B19V and its geographic distribution among voluntary blood donors in Shaanxi Province. Methods: In this cross-sectional study, from August to December 2024, an enzyme-linked immunosorbent assay was used to detect the IgG antibody against B19V in sampled batches of qualified blood samples from five municipal central blood stations in Shaanxi Province, and the distribution characteristics of samples were analysed from multiple perspectives. Results: In Shaanxi Province, the B19V IgG antibody positivity rate was 24.95% (533 out of 2136), and increased with age (p < 0.001). Positive cases showed significant spatial clustering (p < 0.001), with a higher number of positive cases in Central Shaanxi and a lower number of positive cases in Northern and Southern Shaanxi. The infection risks were significantly different between northern and southern regions (odds ratio [OR]: 0.592, 95% confidence interval [CI]: 0.448–0.782, p < 0.001). Compared to type A blood, individuals with type B blood have a lower risk of previous infection (OR: 0.718, 95% CI: 0.549–0.940, p < 0.05). Conclusions: The previous infection rate of B19V is high among blood donors in Shaanxi Province, influenced by age, blood type, and geography. Given that B19V screening is not yet part of routine donor testing in China, we recommend that blood or blood components intended for immunocompromised, high-risk recipients be tested for B19V before transfusion, so as to reduce the risk of transfusion-transmitted infection in an economical and efficient manner. Future studies should focus on the long-term dynamics of B19V infection and the effectiveness of screening programs in reducing transmission risks.
KW - Human parvovirus B19
KW - immunoglobulin G
KW - spatial distribution
KW - transfusion transmission
KW - volunteer blood donors
UR - https://www.scopus.com/pages/publications/105033400927
U2 - 10.1177/00368504261436108
DO - 10.1177/00368504261436108
M3 - 文章
C2 - 41854373
AN - SCOPUS:105033400927
SN - 0036-8504
VL - 109
JO - Science Progress
JF - Science Progress
IS - 1
ER -