Serine synthesis and transport mediate the synergistic and detoxifying effects of lienal peptides on cisplatin

Ke Ding; Tengjie Yu; Xiaowei Zhang; Kangrui Hu; Shuying Mao; Tingting Zhang; Ye Liu; Zhongbo Wang; Xin Fan; Wei Liu; Dianzhui Zhang; Laipeng He; Lin Xie; Guangji Wang; Yan Liang

doi:10.3389/fphar.2025.1646217

Serine synthesis and transport mediate the synergistic and detoxifying effects of lienal peptides on cisplatin

Ke Ding
, Tengjie Yu
, Xiaowei Zhang
, Kangrui Hu
, Shuying Mao
, Tingting Zhang
, Ye Liu
, Zhongbo Wang
, Xin Fan
, Wei Liu
, Dianzhui Zhang
, Laipeng He
, Lin Xie
, Guangji Wang
, Yan Liang

China Pharmaceutical University
Hebei General Hospital
Ltd.

Research output: Contribution to journal › Article › peer-review

Abstract

(Figure presented.)

Original language	English
Article number	1646217
Journal	Frontiers in Pharmacology
Volume	16
DOIs	https://doi.org/10.3389/fphar.2025.1646217
State	Published - 2026
Externally published	Yes

Keywords

cisplatin
lienal peptides
metabolome
serine
SFXN1

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10.3389/fphar.2025.1646217

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@article{e6be715fa49e45cbb16c841e666a5b4f,

title = "Serine synthesis and transport mediate the synergistic and detoxifying effects of lienal peptides on cisplatin",

abstract = "(Figure presented.)",

keywords = "cisplatin, lienal peptides, metabolome, serine, SFXN1",

author = "Ke Ding and Tengjie Yu and Xiaowei Zhang and Kangrui Hu and Shuying Mao and Tingting Zhang and Ye Liu and Zhongbo Wang and Xin Fan and Wei Liu and Dianzhui Zhang and Laipeng He and Lin Xie and Guangji Wang and Yan Liang",

note = "Publisher Copyright: Copyright {\textcopyright} 2026 Ding, Yu, Zhang, Hu, Mao, Zhang, Liu, Wang, Fan, Liu, Zhang, He, Xie, Wang and Liang.",

year = "2026",

doi = "10.3389/fphar.2025.1646217",

language = "英语",

volume = "16",

journal = "Frontiers in Pharmacology",

issn = "1663-9812",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - Serine synthesis and transport mediate the synergistic and detoxifying effects of lienal peptides on cisplatin

AU - Ding, Ke

AU - Yu, Tengjie

AU - Zhang, Xiaowei

AU - Hu, Kangrui

AU - Mao, Shuying

AU - Zhang, Tingting

AU - Liu, Ye

AU - Wang, Zhongbo

AU - Fan, Xin

AU - Liu, Wei

AU - Zhang, Dianzhui

AU - He, Laipeng

AU - Xie, Lin

AU - Wang, Guangji

AU - Liang, Yan

PY - 2026

Y1 - 2026

N2 - (Figure presented.)

AB - (Figure presented.)

KW - cisplatin

KW - lienal peptides

KW - metabolome

KW - serine

KW - SFXN1

UR - https://www.scopus.com/pages/publications/105028942800

U2 - 10.3389/fphar.2025.1646217

DO - 10.3389/fphar.2025.1646217

M3 - 文章

AN - SCOPUS:105028942800

SN - 1663-9812

VL - 16

JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

M1 - 1646217

ER -

Serine synthesis and transport mediate the synergistic and detoxifying effects of lienal peptides on cisplatin

Abstract

Keywords

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