Self-assembly and cytotoxicity study of waterwheel-like dinuclear metal complexes: The first metal complexes appended with multiple free hydroxamic acid groups

Wen Hua Wang; Wei Sheng Liu; Ya Wen Wang; Yang Li; Li Fang Zheng; Da Qi Wang

doi:10.1016/j.jinorgbio.2006.10.002

Self-assembly and cytotoxicity study of waterwheel-like dinuclear metal complexes: The first metal complexes appended with multiple free hydroxamic acid groups

Wen Hua Wang
, Wei Sheng Liu
, Ya Wen Wang
, Yang Li
, Li Fang Zheng
, Da Qi Wang

Lanzhou University
Liaocheng University

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Two waterwheel-like dinuclear complexes [M₂(PHA)₄(H₂O)₂] (M = Cu(II) (1), Zn(II) (2); HPHA = phthal-hydroxamic acid) appended with four free hydroxamic acid groups, namely, free hydroxamic acid metal complexes (FHAMCs) have been synthesized and characterized. The crystal structure of complex 1 was determined by single crystal X-ray diffraction, which adopts the paddlewheel motif with four bidentate carboxylate ligands joining two Cu(II) ions. The relative cytotoxicities of compounds 1 and 2 against SMMC-7721 and HO-8910 cell lines are similar and more predominant than HPHA (IC₅₀: Cu(II) > Zn(II) ≫ HPHA). The synergic effect of the bound water molecules, multiple free hydroxamic acid groups and dimetal active sites with bridging carboxylate may have significant impacts on their pharmacological activity. As the prototype for a new class of hydroxamic acid derivatives, the self-assembly of FHAMCs presents a promising new strategy in designing multiple hydroxamic acids with remarkable bioactivities.

Original language	English
Pages (from-to)	297-304
Number of pages	8
Journal	Journal of Inorganic Biochemistry
Volume	101
Issue number	2
DOIs	https://doi.org/10.1016/j.jinorgbio.2006.10.002
State	Published - Feb 2007
Externally published	Yes

Keywords

Crystal structure
Cytotoxic activity
Free hydroxamic acid metal complexes
Multiple hydroxamic acid
Tetracarboxylatedicopper(II) complexes

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10.1016/j.jinorgbio.2006.10.002

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@article{f49161808cf24404980ebe39e4825c3b,

title = "Self-assembly and cytotoxicity study of waterwheel-like dinuclear metal complexes: The first metal complexes appended with multiple free hydroxamic acid groups",

abstract = "Two waterwheel-like dinuclear complexes [M2(PHA)4(H2O)2] (M = Cu(II) (1), Zn(II) (2); HPHA = phthal-hydroxamic acid) appended with four free hydroxamic acid groups, namely, free hydroxamic acid metal complexes (FHAMCs) have been synthesized and characterized. The crystal structure of complex 1 was determined by single crystal X-ray diffraction, which adopts the paddlewheel motif with four bidentate carboxylate ligands joining two Cu(II) ions. The relative cytotoxicities of compounds 1 and 2 against SMMC-7721 and HO-8910 cell lines are similar and more predominant than HPHA (IC50: Cu(II) > Zn(II) ≫ HPHA). The synergic effect of the bound water molecules, multiple free hydroxamic acid groups and dimetal active sites with bridging carboxylate may have significant impacts on their pharmacological activity. As the prototype for a new class of hydroxamic acid derivatives, the self-assembly of FHAMCs presents a promising new strategy in designing multiple hydroxamic acids with remarkable bioactivities.",

keywords = "Crystal structure, Cytotoxic activity, Free hydroxamic acid metal complexes, Multiple hydroxamic acid, Tetracarboxylatedicopper(II) complexes",

author = "Wang, \{Wen Hua\} and Liu, \{Wei Sheng\} and Wang, \{Ya Wen\} and Yang Li and Zheng, \{Li Fang\} and Wang, \{Da Qi\}",

year = "2007",

month = feb,

doi = "10.1016/j.jinorgbio.2006.10.002",

language = "英语",

volume = "101",

pages = "297--304",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

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}

TY - JOUR

T1 - Self-assembly and cytotoxicity study of waterwheel-like dinuclear metal complexes

T2 - The first metal complexes appended with multiple free hydroxamic acid groups

AU - Wang, Wen Hua

AU - Liu, Wei Sheng

AU - Wang, Ya Wen

AU - Li, Yang

AU - Zheng, Li Fang

AU - Wang, Da Qi

PY - 2007/2

Y1 - 2007/2

N2 - Two waterwheel-like dinuclear complexes [M2(PHA)4(H2O)2] (M = Cu(II) (1), Zn(II) (2); HPHA = phthal-hydroxamic acid) appended with four free hydroxamic acid groups, namely, free hydroxamic acid metal complexes (FHAMCs) have been synthesized and characterized. The crystal structure of complex 1 was determined by single crystal X-ray diffraction, which adopts the paddlewheel motif with four bidentate carboxylate ligands joining two Cu(II) ions. The relative cytotoxicities of compounds 1 and 2 against SMMC-7721 and HO-8910 cell lines are similar and more predominant than HPHA (IC50: Cu(II) > Zn(II) ≫ HPHA). The synergic effect of the bound water molecules, multiple free hydroxamic acid groups and dimetal active sites with bridging carboxylate may have significant impacts on their pharmacological activity. As the prototype for a new class of hydroxamic acid derivatives, the self-assembly of FHAMCs presents a promising new strategy in designing multiple hydroxamic acids with remarkable bioactivities.

AB - Two waterwheel-like dinuclear complexes [M2(PHA)4(H2O)2] (M = Cu(II) (1), Zn(II) (2); HPHA = phthal-hydroxamic acid) appended with four free hydroxamic acid groups, namely, free hydroxamic acid metal complexes (FHAMCs) have been synthesized and characterized. The crystal structure of complex 1 was determined by single crystal X-ray diffraction, which adopts the paddlewheel motif with four bidentate carboxylate ligands joining two Cu(II) ions. The relative cytotoxicities of compounds 1 and 2 against SMMC-7721 and HO-8910 cell lines are similar and more predominant than HPHA (IC50: Cu(II) > Zn(II) ≫ HPHA). The synergic effect of the bound water molecules, multiple free hydroxamic acid groups and dimetal active sites with bridging carboxylate may have significant impacts on their pharmacological activity. As the prototype for a new class of hydroxamic acid derivatives, the self-assembly of FHAMCs presents a promising new strategy in designing multiple hydroxamic acids with remarkable bioactivities.

KW - Crystal structure

KW - Cytotoxic activity

KW - Free hydroxamic acid metal complexes

KW - Multiple hydroxamic acid

KW - Tetracarboxylatedicopper(II) complexes

UR - https://www.scopus.com/pages/publications/33846033459

U2 - 10.1016/j.jinorgbio.2006.10.002

DO - 10.1016/j.jinorgbio.2006.10.002

M3 - 文章

C2 - 17125839

AN - SCOPUS:33846033459

SN - 0162-0134

VL - 101

SP - 297

EP - 304

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 2

ER -

Self-assembly and cytotoxicity study of waterwheel-like dinuclear metal complexes: The first metal complexes appended with multiple free hydroxamic acid groups

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Keywords

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