Scale-Up Considerations for Biofuels

David Humbird; Qiang Fei

doi:10.1016/B978-0-444-63475-7.00020-0

Scale-Up Considerations for Biofuels

David Humbird
, Qiang Fei

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

32 Scopus citations

Abstract

In order to measurably displace fossil fuels in the near term, companies looking to commercialize a biofuel technology must expect to operate at levels of scale, efficiency, and margin that are unprecedented in the biotechnology industry to date. This chapter discusses high-level technical and economic challenges that many technologies will face at industrial scale. Culture and process optimization strategies and culture oxygen demand reduction are discussed, along with basic bioreactor scale-up principles and aeration process economics. Methodologies and techniques for culture optimization are also discussed and compared, including design of experiments, response surface methodology, artificial neural network, fuzzy logic, genetic algorithm, and optimization tools.

Original language	English
Title of host publication	Biotechnology for Biofuel Production and Optimization
Publisher	Elsevier Inc.
Pages	513-537
Number of pages	25
ISBN (Print)	9780444634757
DOIs	https://doi.org/10.1016/B978-0-444-63475-7.00020-0
State	Published - 20 Jan 2016
Externally published	Yes

Keywords

Biofuel production
Bioprocess development
Cultivation condition optimization
Design of experiments
Fermentation scale-up
Oxygen usage reduction
Response surface methodology
Technoeconomic analysis

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10.1016/B978-0-444-63475-7.00020-0

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abstract = "In order to measurably displace fossil fuels in the near term, companies looking to commercialize a biofuel technology must expect to operate at levels of scale, efficiency, and margin that are unprecedented in the biotechnology industry to date. This chapter discusses high-level technical and economic challenges that many technologies will face at industrial scale. Culture and process optimization strategies and culture oxygen demand reduction are discussed, along with basic bioreactor scale-up principles and aeration process economics. Methodologies and techniques for culture optimization are also discussed and compared, including design of experiments, response surface methodology, artificial neural network, fuzzy logic, genetic algorithm, and optimization tools.",

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AU - Fei, Qiang

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AB - In order to measurably displace fossil fuels in the near term, companies looking to commercialize a biofuel technology must expect to operate at levels of scale, efficiency, and margin that are unprecedented in the biotechnology industry to date. This chapter discusses high-level technical and economic challenges that many technologies will face at industrial scale. Culture and process optimization strategies and culture oxygen demand reduction are discussed, along with basic bioreactor scale-up principles and aeration process economics. Methodologies and techniques for culture optimization are also discussed and compared, including design of experiments, response surface methodology, artificial neural network, fuzzy logic, genetic algorithm, and optimization tools.

KW - Biofuel production

KW - Bioprocess development

KW - Cultivation condition optimization

KW - Design of experiments

KW - Fermentation scale-up

KW - Oxygen usage reduction

KW - Response surface methodology

KW - Technoeconomic analysis

UR - https://www.scopus.com/pages/publications/84967321438

U2 - 10.1016/B978-0-444-63475-7.00020-0

DO - 10.1016/B978-0-444-63475-7.00020-0

M3 - 章节

AN - SCOPUS:84967321438

SN - 9780444634757

SP - 513

EP - 537

BT - Biotechnology for Biofuel Production and Optimization

PB - Elsevier Inc.

ER -

Scale-Up Considerations for Biofuels

Abstract

Keywords

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