Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: An updated meta-analysis

Zhi Ming Dai; Tian Song Zhang; Shuai Lin; Wang Gang Zhang; Jie Liu; Xing Mei Cao; Hong Bao Li; Meng Wang; Xing Han Liu; Kang Liu; Shan Li Li; Zhi Jun Dai

doi:10.1038/srep20439

Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: An updated meta-analysis

Zhi Ming Dai
, Tian Song Zhang
, Shuai Lin
, Wang Gang Zhang
, Jie Liu
, Xing Mei Cao
, Hong Bao Li
, Meng Wang
, Xing Han Liu
, Kang Liu
, Shan Li Li
, Zhi Jun Dai

Health Science Center

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Single nucleotide polymorphisms (SNPs) in the interleukin-17 (IL-17) gene have been shown to be correlated with susceptibility to cancer. However, various studies report different results of this association. The aim of the present work was to clarify the effects of IL-17A G197A (rs2275913) and IL-17F T7488C (rs763780) polymorphisms on cancer risk. We performed systematic searches of the PubMed and CNKI databases to obtain relevant publications. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association of rs2275913 and rs763780 polymorphisms with cancer risk. Data were extracted from the selected studies, and statistical analysis was conducted using the STATA software. Our results indicated that rs2275913 and rs763780 polymorphisms significantly increase cancer risk, especially in gastric cancers. Subgroup analysis suggested the existence of a significant correlation between rs763780 polymorphism and cancer susceptibility in Caucasian populations. This updated meta-analysis confirms that rs2275913 and rs763780 polymorphisms are highly associated with increased risk for multiple forms of cancer.

Original language	English
Article number	20439
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep20439
State	Published - 4 Feb 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/srep20439

Cite this

@article{db13e8083d694a6c8ce7e9282b2d76f2,

title = "Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: An updated meta-analysis",

abstract = "Single nucleotide polymorphisms (SNPs) in the interleukin-17 (IL-17) gene have been shown to be correlated with susceptibility to cancer. However, various studies report different results of this association. The aim of the present work was to clarify the effects of IL-17A G197A (rs2275913) and IL-17F T7488C (rs763780) polymorphisms on cancer risk. We performed systematic searches of the PubMed and CNKI databases to obtain relevant publications. Odds ratios (ORs) with 95\% confidence intervals (CIs) were used to evaluate the association of rs2275913 and rs763780 polymorphisms with cancer risk. Data were extracted from the selected studies, and statistical analysis was conducted using the STATA software. Our results indicated that rs2275913 and rs763780 polymorphisms significantly increase cancer risk, especially in gastric cancers. Subgroup analysis suggested the existence of a significant correlation between rs763780 polymorphism and cancer susceptibility in Caucasian populations. This updated meta-analysis confirms that rs2275913 and rs763780 polymorphisms are highly associated with increased risk for multiple forms of cancer.",

author = "Dai, \{Zhi Ming\} and Zhang, \{Tian Song\} and Shuai Lin and Zhang, \{Wang Gang\} and Jie Liu and Cao, \{Xing Mei\} and Li, \{Hong Bao\} and Meng Wang and Liu, \{Xing Han\} and Kang Liu and Li, \{Shan Li\} and Dai, \{Zhi Jun\}",

year = "2016",

month = feb,

day = "4",

doi = "10.1038/srep20439",

language = "英语",

volume = "6",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Research",

}

TY - JOUR

T1 - Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development

T2 - An updated meta-analysis

AU - Dai, Zhi Ming

AU - Zhang, Tian Song

AU - Lin, Shuai

AU - Zhang, Wang Gang

AU - Liu, Jie

AU - Cao, Xing Mei

AU - Li, Hong Bao

AU - Wang, Meng

AU - Liu, Xing Han

AU - Liu, Kang

AU - Li, Shan Li

AU - Dai, Zhi Jun

PY - 2016/2/4

Y1 - 2016/2/4

N2 - Single nucleotide polymorphisms (SNPs) in the interleukin-17 (IL-17) gene have been shown to be correlated with susceptibility to cancer. However, various studies report different results of this association. The aim of the present work was to clarify the effects of IL-17A G197A (rs2275913) and IL-17F T7488C (rs763780) polymorphisms on cancer risk. We performed systematic searches of the PubMed and CNKI databases to obtain relevant publications. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association of rs2275913 and rs763780 polymorphisms with cancer risk. Data were extracted from the selected studies, and statistical analysis was conducted using the STATA software. Our results indicated that rs2275913 and rs763780 polymorphisms significantly increase cancer risk, especially in gastric cancers. Subgroup analysis suggested the existence of a significant correlation between rs763780 polymorphism and cancer susceptibility in Caucasian populations. This updated meta-analysis confirms that rs2275913 and rs763780 polymorphisms are highly associated with increased risk for multiple forms of cancer.

AB - Single nucleotide polymorphisms (SNPs) in the interleukin-17 (IL-17) gene have been shown to be correlated with susceptibility to cancer. However, various studies report different results of this association. The aim of the present work was to clarify the effects of IL-17A G197A (rs2275913) and IL-17F T7488C (rs763780) polymorphisms on cancer risk. We performed systematic searches of the PubMed and CNKI databases to obtain relevant publications. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association of rs2275913 and rs763780 polymorphisms with cancer risk. Data were extracted from the selected studies, and statistical analysis was conducted using the STATA software. Our results indicated that rs2275913 and rs763780 polymorphisms significantly increase cancer risk, especially in gastric cancers. Subgroup analysis suggested the existence of a significant correlation between rs763780 polymorphism and cancer susceptibility in Caucasian populations. This updated meta-analysis confirms that rs2275913 and rs763780 polymorphisms are highly associated with increased risk for multiple forms of cancer.

UR - https://www.scopus.com/pages/publications/84957536249

U2 - 10.1038/srep20439

DO - 10.1038/srep20439

M3 - 文章

C2 - 26843459

AN - SCOPUS:84957536249

SN - 2045-2322

VL - 6

JO - Scientific Reports

JF - Scientific Reports

M1 - 20439

ER -

Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: An updated meta-analysis

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this