Abstract
Biocompatible polymeric nanocarriers can improve the solubility of many toxic anticancer drugs, prolong the in vivo drug circulation time, and allow preferential accumulation of the drugs at the tumor sites via the enhanced permeability and retention effect. To maximize the stability of the nanocarrier and minimize premature drug release during circulation, intraparticle or intramicellar cross-links can be introduced. In this chapter, we will summarize the development of reversibly cross-linked polymeric nanocarriers for on-demand drug release in response to single or multiple stimuli at the tumor microenvironment.
| Original language | English |
|---|---|
| Title of host publication | Nanoengineered Biomaterials for Advanced Drug Delivery |
| Publisher | Elsevier |
| Pages | 243-260 |
| Number of pages | 18 |
| ISBN (Electronic) | 9780081029855 |
| DOIs | |
| State | Published - 1 Jan 2020 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cancer therapy
- Chemotherapy
- Cross-links
- Drug delivery
- Nanocarrier
- Nanodelivery
- Nanomedicine
- Nanotheranostics
- Nanotherapeutics
- Reversible cross-links
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