Release the autophage brake on inflammation: The MAPK14/p38α-ULK1 pedal

Hua She; Yingli He; Yingren Zhao; Zixu Mao

doi:10.1080/15548627.2018.1446626

Release the autophage brake on inflammation: The MAPK14/p38α-ULK1 pedal

Hua She
, Yingli He
, Yingren Zhao
, Zixu Mao

Health Science Center

Research output: Contribution to journal › Comment/debate

26 Scopus citations

Abstract

Macroautophagy/autophagy and inflammation are 2 intertwined processes vital for immune cells to perform their functions. Under resting conditions, autophagy acts as a brake to suppress inflammation in microglia. Upon signal stimulation, their fine-tuned interplay is pivotal for proper response to stress. How inflammatory signals remove this autophagy brake on inflammation remains unclear. In a recent study, we showed that the stress kinase MAPK14/p38α in microglia senses the inflammatory cue lipopolysaccharide (LPS), directly phosphorylates and inhibits ULK1, relieves the autophagic inhibition on the inflammatory machinery, and thus allows for a full immune response.

Original language	English
Pages (from-to)	1097-1098
Number of pages	2
Journal	Autophagy
Volume	14
Issue number	6
DOIs	https://doi.org/10.1080/15548627.2018.1446626
State	Published - 3 Jun 2018

Keywords

MAPK14/p38α
ULK1
autophagy
inflammation
microglia

Access to Document

10.1080/15548627.2018.1446626

Cite this

@article{5518890805fc4956b710c09a98f56eea,

title = "Release the autophage brake on inflammation: The MAPK14/p38α-ULK1 pedal",

abstract = "Macroautophagy/autophagy and inflammation are 2 intertwined processes vital for immune cells to perform their functions. Under resting conditions, autophagy acts as a brake to suppress inflammation in microglia. Upon signal stimulation, their fine-tuned interplay is pivotal for proper response to stress. How inflammatory signals remove this autophagy brake on inflammation remains unclear. In a recent study, we showed that the stress kinase MAPK14/p38α in microglia senses the inflammatory cue lipopolysaccharide (LPS), directly phosphorylates and inhibits ULK1, relieves the autophagic inhibition on the inflammatory machinery, and thus allows for a full immune response.",

keywords = "MAPK14/p38α, ULK1, autophagy, inflammation, microglia",

author = "Hua She and Yingli He and Yingren Zhao and Zixu Mao",

note = "Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 Informa UK Limited, trading as Taylor \& Francis Group.",

year = "2018",

month = jun,

day = "3",

doi = "10.1080/15548627.2018.1446626",

language = "英语",

volume = "14",

pages = "1097--1098",

journal = "Autophagy",

issn = "1554-8627",

publisher = "Taylor and Francis Ltd.",

number = "6",

}

TY - JOUR

T1 - Release the autophage brake on inflammation

T2 - The MAPK14/p38α-ULK1 pedal

AU - She, Hua

AU - He, Yingli

AU - Zhao, Yingren

AU - Mao, Zixu

PY - 2018/6/3

Y1 - 2018/6/3

N2 - Macroautophagy/autophagy and inflammation are 2 intertwined processes vital for immune cells to perform their functions. Under resting conditions, autophagy acts as a brake to suppress inflammation in microglia. Upon signal stimulation, their fine-tuned interplay is pivotal for proper response to stress. How inflammatory signals remove this autophagy brake on inflammation remains unclear. In a recent study, we showed that the stress kinase MAPK14/p38α in microglia senses the inflammatory cue lipopolysaccharide (LPS), directly phosphorylates and inhibits ULK1, relieves the autophagic inhibition on the inflammatory machinery, and thus allows for a full immune response.

AB - Macroautophagy/autophagy and inflammation are 2 intertwined processes vital for immune cells to perform their functions. Under resting conditions, autophagy acts as a brake to suppress inflammation in microglia. Upon signal stimulation, their fine-tuned interplay is pivotal for proper response to stress. How inflammatory signals remove this autophagy brake on inflammation remains unclear. In a recent study, we showed that the stress kinase MAPK14/p38α in microglia senses the inflammatory cue lipopolysaccharide (LPS), directly phosphorylates and inhibits ULK1, relieves the autophagic inhibition on the inflammatory machinery, and thus allows for a full immune response.

KW - MAPK14/p38α

KW - ULK1

KW - autophagy

KW - inflammation

KW - microglia

UR - https://www.scopus.com/pages/publications/85046805503

U2 - 10.1080/15548627.2018.1446626

DO - 10.1080/15548627.2018.1446626

M3 - 评论/辩论

C2 - 29749797

AN - SCOPUS:85046805503

SN - 1554-8627

VL - 14

SP - 1097

EP - 1098

JO - Autophagy

JF - Autophagy

IS - 6

ER -

Release the autophage brake on inflammation: The MAPK14/p38α-ULK1 pedal

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this