Relationship of gastrointestinal hormone with duodenogastric reflux and interdigestive antroduodenal migrating moter complex

Objective: To study the relationship of gastrointestinal hormone with duodenogastric reflux (DGR) and interdigestive antroduodenal migrating moter complex(MMC). Methods: Antroduodenal manometry, simultaneous 24-hour intragastric pH and Bilitec monitoring were carried out in 20 healthy volunteers overnight for a long time. Blood samples were drawn at episodes of alkaline reflux and/or bile reflux, and after reflux, as well as at interdigestive MMC phase I, II and III, respectively and were detected for motilin, substance P, somatostatin and nitric oxide. Results: The serum concentration of NO was significantly increased during alkaline reflux [(98.23± 12.14) μmol·L^-1 and (71.24±10.21) μmol·L ^-1, P<0.01] and bile reflux [(87.32±11.46) μmol·L^-1 and (69.45±10.56) μmol·L ^-1, P<0.05] compared to no episodes of DGR. The concentrations of MTL, SP and SS were not different between alkaline or bile reflux and no episodes of DGR. The plasma concentration of MTL was higher in phase III than in phase I (P<0.05) and phase II (P<0.05). The concentrations of SP, SS and NO did not differ among each phase of MMC. Conclusion: DGR may be related to increased concentration of NO, and MMC phase III is related to the concentration of MTL.