Relation between polymorphism of dopamine receptor gene and acute stresss disorder

Lei Ma; Jia Tong Wang; Fu En Huang; Dan Min Miao; Qing Shu; Qing Rong Tan; Zun Xiao Dai; Ya Ning Wei

Relation between polymorphism of dopamine receptor gene and acute stresss disorder

Lei Ma
, Jia Tong Wang
, Fu En Huang
, Dan Min Miao
, Qing Shu
, Qing Rong Tan
, Zun Xiao Dai
, Ya Ning Wei

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Aim: To explore the relation between the polymorphism of dopamine receptor D₂(DRD₂) Taq I and the genetic susceptibility of acute stress disorder (ASD). Methods: PCR-RFLP was used to determine the DRD₂ Taq I A polymorphism of 23 patients with ASD. Another 41 survivors, who had experienced serious traffic or other accidents, were involved in the control group. Results: There were significant differences in A1 allele frequencies (f_A1) between the ASD group (43.5%) and the control group (24.4%) (χ² = 4.998, P < 0.05). There were also significant differences in allele carrying rate between the ASD group (73.9%) and the control group (43.9%) (χ² = 5.355, P < 0.05). Conclusion: Polymorphism of DRD₂ Taq I is related to the ASD, and A1 alleles carrier may be susceptibile to ASD.

Original language	English
Pages (from-to)	1086-1087
Number of pages	2
Journal	Chinese Journal of Clinical Rehabilitation
Volume	8
Issue number	6
State	Published - Feb 2004
Externally published	Yes

Cite this

@article{207466b7885e47f790374c3b0ba52749,

title = "Relation between polymorphism of dopamine receptor gene and acute stresss disorder",

abstract = "Aim: To explore the relation between the polymorphism of dopamine receptor D2(DRD2) Taq I and the genetic susceptibility of acute stress disorder (ASD). Methods: PCR-RFLP was used to determine the DRD2 Taq I A polymorphism of 23 patients with ASD. Another 41 survivors, who had experienced serious traffic or other accidents, were involved in the control group. Results: There were significant differences in A1 allele frequencies (fA1) between the ASD group (43.5\%) and the control group (24.4\%) (χ2 = 4.998, P < 0.05). There were also significant differences in allele carrying rate between the ASD group (73.9\%) and the control group (43.9\%) (χ2 = 5.355, P < 0.05). Conclusion: Polymorphism of DRD2 Taq I is related to the ASD, and A1 alleles carrier may be susceptibile to ASD.",

author = "Lei Ma and Wang, \{Jia Tong\} and Huang, \{Fu En\} and Miao, \{Dan Min\} and Qing Shu and Tan, \{Qing Rong\} and Dai, \{Zun Xiao\} and Wei, \{Ya Ning\}",

year = "2004",

month = feb,

language = "英语",

volume = "8",

pages = "1086--1087",

journal = "Chinese Journal of Clinical Rehabilitation",

issn = "1671-5926",

publisher = "Zhongguo Lin Chuang Kang Fu",

number = "6",

}

TY - JOUR

T1 - Relation between polymorphism of dopamine receptor gene and acute stresss disorder

AU - Ma, Lei

AU - Wang, Jia Tong

AU - Huang, Fu En

AU - Miao, Dan Min

AU - Shu, Qing

AU - Tan, Qing Rong

AU - Dai, Zun Xiao

AU - Wei, Ya Ning

PY - 2004/2

Y1 - 2004/2

N2 - Aim: To explore the relation between the polymorphism of dopamine receptor D2(DRD2) Taq I and the genetic susceptibility of acute stress disorder (ASD). Methods: PCR-RFLP was used to determine the DRD2 Taq I A polymorphism of 23 patients with ASD. Another 41 survivors, who had experienced serious traffic or other accidents, were involved in the control group. Results: There were significant differences in A1 allele frequencies (fA1) between the ASD group (43.5%) and the control group (24.4%) (χ2 = 4.998, P < 0.05). There were also significant differences in allele carrying rate between the ASD group (73.9%) and the control group (43.9%) (χ2 = 5.355, P < 0.05). Conclusion: Polymorphism of DRD2 Taq I is related to the ASD, and A1 alleles carrier may be susceptibile to ASD.

AB - Aim: To explore the relation between the polymorphism of dopamine receptor D2(DRD2) Taq I and the genetic susceptibility of acute stress disorder (ASD). Methods: PCR-RFLP was used to determine the DRD2 Taq I A polymorphism of 23 patients with ASD. Another 41 survivors, who had experienced serious traffic or other accidents, were involved in the control group. Results: There were significant differences in A1 allele frequencies (fA1) between the ASD group (43.5%) and the control group (24.4%) (χ2 = 4.998, P < 0.05). There were also significant differences in allele carrying rate between the ASD group (73.9%) and the control group (43.9%) (χ2 = 5.355, P < 0.05). Conclusion: Polymorphism of DRD2 Taq I is related to the ASD, and A1 alleles carrier may be susceptibile to ASD.

UR - https://www.scopus.com/pages/publications/2442503473

M3 - 文章

AN - SCOPUS:2442503473

SN - 1671-5926

VL - 8

SP - 1086

EP - 1087

JO - Chinese Journal of Clinical Rehabilitation

JF - Chinese Journal of Clinical Rehabilitation

IS - 6

ER -

Relation between polymorphism of dopamine receptor gene and acute stresss disorder

Abstract

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