Redox-responsive, core cross-linked polyester micelles

Zhonghai Zhang; Lichen Yin; Chunlai Tu; Ziyuan Song; Yanfeng Zhang; Yunxiang Xu; Rong Tong; Qin Zhou; Jie Ren; Jianjun Cheng

doi:10.1021/mz300522n

Redox-responsive, core cross-linked polyester micelles

Zhonghai Zhang
, Lichen Yin
, Chunlai Tu
, Ziyuan Song
, Yanfeng Zhang
, Yunxiang Xu
, Rong Tong
, Qin Zhou
, Jie Ren
, Jianjun Cheng

University of Illinois at Urbana-Champaign
Tongji University
Guangdong Pharmaceutical University

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

Monomethoxy poly(ethylene glycol)-b-poly(Tyr(alkynyl)-OCA), a biodegradable amphiphilic block copolymer, was synthesized by means of ring-opening polymerization of 5-(4-(prop-2-yn-1-yloxy)benzyl)-1,3-dioxolane-2,4-dione (Tyr(alkynyl)-OCA) and used to prepare core cross-linked polyester micelles via click chemistry. Core cross-linking not only improved the structural stability of the micelles, but also allowed controlled release of cargo molecules in response to the reducing reagent. This new class of core cross-linked micelles can potentially be used in controlled release and drug delivery applications.

Original language	English
Pages (from-to)	40-44
Number of pages	5
Journal	ACS Macro Letters
Volume	2
Issue number	1
DOIs	https://doi.org/10.1021/mz300522n
State	Published - 15 Jan 2013
Externally published	Yes

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10.1021/mz300522n

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title = "Redox-responsive, core cross-linked polyester micelles",

abstract = "Monomethoxy poly(ethylene glycol)-b-poly(Tyr(alkynyl)-OCA), a biodegradable amphiphilic block copolymer, was synthesized by means of ring-opening polymerization of 5-(4-(prop-2-yn-1-yloxy)benzyl)-1,3-dioxolane-2,4-dione (Tyr(alkynyl)-OCA) and used to prepare core cross-linked polyester micelles via click chemistry. Core cross-linking not only improved the structural stability of the micelles, but also allowed controlled release of cargo molecules in response to the reducing reagent. This new class of core cross-linked micelles can potentially be used in controlled release and drug delivery applications.",

author = "Zhonghai Zhang and Lichen Yin and Chunlai Tu and Ziyuan Song and Yanfeng Zhang and Yunxiang Xu and Rong Tong and Qin Zhou and Jie Ren and Jianjun Cheng",

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day = "15",

doi = "10.1021/mz300522n",

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TY - JOUR

T1 - Redox-responsive, core cross-linked polyester micelles

AU - Zhang, Zhonghai

AU - Yin, Lichen

AU - Tu, Chunlai

AU - Song, Ziyuan

AU - Zhang, Yanfeng

AU - Xu, Yunxiang

AU - Tong, Rong

AU - Zhou, Qin

AU - Ren, Jie

AU - Cheng, Jianjun

PY - 2013/1/15

Y1 - 2013/1/15

N2 - Monomethoxy poly(ethylene glycol)-b-poly(Tyr(alkynyl)-OCA), a biodegradable amphiphilic block copolymer, was synthesized by means of ring-opening polymerization of 5-(4-(prop-2-yn-1-yloxy)benzyl)-1,3-dioxolane-2,4-dione (Tyr(alkynyl)-OCA) and used to prepare core cross-linked polyester micelles via click chemistry. Core cross-linking not only improved the structural stability of the micelles, but also allowed controlled release of cargo molecules in response to the reducing reagent. This new class of core cross-linked micelles can potentially be used in controlled release and drug delivery applications.

AB - Monomethoxy poly(ethylene glycol)-b-poly(Tyr(alkynyl)-OCA), a biodegradable amphiphilic block copolymer, was synthesized by means of ring-opening polymerization of 5-(4-(prop-2-yn-1-yloxy)benzyl)-1,3-dioxolane-2,4-dione (Tyr(alkynyl)-OCA) and used to prepare core cross-linked polyester micelles via click chemistry. Core cross-linking not only improved the structural stability of the micelles, but also allowed controlled release of cargo molecules in response to the reducing reagent. This new class of core cross-linked micelles can potentially be used in controlled release and drug delivery applications.

UR - https://www.scopus.com/pages/publications/84872588576

U2 - 10.1021/mz300522n

DO - 10.1021/mz300522n

M3 - 文章

AN - SCOPUS:84872588576

SN - 2161-1653

VL - 2

SP - 40

EP - 44

JO - ACS Macro Letters

JF - ACS Macro Letters

IS - 1

ER -

Redox-responsive, core cross-linked polyester micelles

Abstract

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