Recent Progress in Phase Regulation, Functionalization, and Biosensing Applications of Polyphase MoS₂

The disulfide compounds of molybdenum (MoS₂) are layered van der Waals materials that exhibit a rich array of polymorphic structures. MoS₂ can be roughly divided into semiconductive phase and metallic phase according to the difference in electron filling state of the 4d orbital of Mo atom. The two phases show completely different properties, leading to their diverse applications in biosensors. But to some extent, they compensate for each other. This review first introduces the relationship between phase state and the chemical/physical structures and properties of MoS₂. Furthermore, the synthetic methods are summarized and the preparation strategies for metastable phases are highlighted. In addition, examples of electronic and chemical property designs of MoS₂ by means of doping and surface modification are outlined. Finally, studies on biosensors based on MoS₂ in recent years are presented and classified, and the roles of MoS₂ with different phases are highlighted. This review offers references for the selection of materials to construct different types of biosensors based on MoS₂, and provides inspiration for sensing performance enhancement.