TY - JOUR
T1 - Quantification of 10 steroid hormones in human saliva from Chinese adult volunteers
AU - Liu, Jian
AU - Qiu, Xuemei
AU - Wang, Daoming
AU - Li, Yantao
AU - Zong, Yang
AU - Liu, Yichen
AU - Zhang, Yue
AU - Yang, Ping
AU - Zuo, Yong
AU - Yang, Huanming
AU - Wang, Jian
AU - Du, Yutao
AU - Zi, Jin
N1 - Publisher Copyright:
© 2018, © The Author(s) 2018.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Objective: This study was performed to investigate the effects of age and sex on 10 salivary steroid hormones and analyze the correlations between salivary and plasma hormones. Methods: The concentrations of 10 salivary steroid hormones in 1090 Chinese adult volunteers were examined using liquid chromatography–tandem mass spectrometry, and a related investigation was performed on the concentrations of salivary hormones in this population. Results: The concentrations of androstenedione (A4), 17α-hydroxyprogesterone (17-OHP), aldosterone (ALD), cortisone (COR), corticosterone (CORT), cortisol (F), progesterone (P), and testosterone were significantly different between men and women (Student’s t-test). Differences in 17-OHP and ALD concentrations were highly significant between women in the follicular and luteal phases of their menstrual cycle (Student’s t-test). Five salivary steroid hormones (17-OHP, A4, CORT, COR, and F) significantly decreased with increasing age (Kruskal–Wallis test). A high linear correlation between salivary and plasma 17-OHP, P, A4, and F were observed with obvious sex-related differences (Pearson’s correlation, r > 0.7). Conclusions: Our results provide important knowledge regarding the descriptive characteristics of salivary hormones in relation to age and sex and their correlations with plasma hormones.
AB - Objective: This study was performed to investigate the effects of age and sex on 10 salivary steroid hormones and analyze the correlations between salivary and plasma hormones. Methods: The concentrations of 10 salivary steroid hormones in 1090 Chinese adult volunteers were examined using liquid chromatography–tandem mass spectrometry, and a related investigation was performed on the concentrations of salivary hormones in this population. Results: The concentrations of androstenedione (A4), 17α-hydroxyprogesterone (17-OHP), aldosterone (ALD), cortisone (COR), corticosterone (CORT), cortisol (F), progesterone (P), and testosterone were significantly different between men and women (Student’s t-test). Differences in 17-OHP and ALD concentrations were highly significant between women in the follicular and luteal phases of their menstrual cycle (Student’s t-test). Five salivary steroid hormones (17-OHP, A4, CORT, COR, and F) significantly decreased with increasing age (Kruskal–Wallis test). A high linear correlation between salivary and plasma 17-OHP, P, A4, and F were observed with obvious sex-related differences (Pearson’s correlation, r > 0.7). Conclusions: Our results provide important knowledge regarding the descriptive characteristics of salivary hormones in relation to age and sex and their correlations with plasma hormones.
KW - age
KW - Chinese
KW - LC-MS/MS
KW - plasma
KW - Saliva
KW - sex
KW - steroid hormones
UR - https://www.scopus.com/pages/publications/85044831087
U2 - 10.1177/0300060517752733
DO - 10.1177/0300060517752733
M3 - 文章
C2 - 29468906
AN - SCOPUS:85044831087
SN - 0300-0605
VL - 46
SP - 1414
EP - 1427
JO - Journal of International Medical Research
JF - Journal of International Medical Research
IS - 4
ER -