Progress in research on immunogenicity of induced pluripotent stem cells

In 2006, scientists introduced a series of transcription factors into mouse fibroblast cells and obtained a kind of pluripotency cells, similar to embryonic stem cells, which were named as induced pluripotent stem cells (iPS cells). The iPS cells could hold strong ability to undergo both self-renewal and differentiation and further avoid traditional ethics problem of embryonic stem cells. Especially, this technology makes it easy to realize auto-trsplantation and promotes the clinical application of stem cells. Great progress has been made in inducing method and efficiency. However, whether the immunogenicity of iPS cells changes during the induction and redifferentiation process remains unknown. This paper reviews the progress in research on immunogenicity of iPS cells in recent years.