Prognostic nutritional index as a prognostic biomarker for survival in digestive system carcinomas

Yang Zhao; Peng Xu; Huafeng Kang; Shuai Lin; Meng Wang; Pengtao Yang; Cong Dai; Xinghan Liu; Kang Liu; Yi Zheng; Zhijun Dai

doi:10.18632/oncotarget.13472

Prognostic nutritional index as a prognostic biomarker for survival in digestive system carcinomas

Yang Zhao
, Peng Xu
, Huafeng Kang
, Shuai Lin
, Meng Wang
, Pengtao Yang
, Cong Dai
, Xinghan Liu
, Kang Liu
, Yi Zheng
, Zhijun Dai

The Second Affiliated Hospital of Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patients with various malignancies. We performed a meta-analysis to determine the predictive potential of PNI in digestive system cancers. Twenty-three studies with a total of 7,384 patients suffering from digestive system carcinomas were involved in this meta-analysis. A lower PNI was significantly associated with the shorter overall survival (OS) [Hazard Ratio (HR) 1.83, 95% Confidence Interval (CI) 1.62-2.07], the poorer disease-free survival (DFS) (HR 1.85, 95% CI 1.19-2.89), and the higher rate of post-operative complications (HR 2.31, 95% CI 1.63-3.28). In conclusion, PNI was allowed to function as an efficient indicator for the prognosis of patients with digestive system carcinomas.

Original language	English
Pages (from-to)	86573-86583
Number of pages	11
Journal	Oncotarget
Volume	7
Issue number	52
DOIs	https://doi.org/10.18632/oncotarget.13472
State	Published - 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Digestive system carcinomas
Meta-analysis
Prognosis
Prognostic nutritional index

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10.18632/oncotarget.13472

Cite this

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title = "Prognostic nutritional index as a prognostic biomarker for survival in digestive system carcinomas",

abstract = "The prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patients with various malignancies. We performed a meta-analysis to determine the predictive potential of PNI in digestive system cancers. Twenty-three studies with a total of 7,384 patients suffering from digestive system carcinomas were involved in this meta-analysis. A lower PNI was significantly associated with the shorter overall survival (OS) [Hazard Ratio (HR) 1.83, 95\% Confidence Interval (CI) 1.62-2.07], the poorer disease-free survival (DFS) (HR 1.85, 95\% CI 1.19-2.89), and the higher rate of post-operative complications (HR 2.31, 95\% CI 1.63-3.28). In conclusion, PNI was allowed to function as an efficient indicator for the prognosis of patients with digestive system carcinomas.",

keywords = "Digestive system carcinomas, Meta-analysis, Prognosis, Prognostic nutritional index",

author = "Yang Zhao and Peng Xu and Huafeng Kang and Shuai Lin and Meng Wang and Pengtao Yang and Cong Dai and Xinghan Liu and Kang Liu and Yi Zheng and Zhijun Dai",

year = "2016",

doi = "10.18632/oncotarget.13472",

language = "英语",

volume = "7",

pages = "86573--86583",

journal = "Oncotarget",

issn = "1949-2553",

publisher = "Impact Journals LLC",

number = "52",

}

TY - JOUR

T1 - Prognostic nutritional index as a prognostic biomarker for survival in digestive system carcinomas

AU - Zhao, Yang

AU - Xu, Peng

AU - Kang, Huafeng

AU - Lin, Shuai

AU - Wang, Meng

AU - Yang, Pengtao

AU - Dai, Cong

AU - Liu, Xinghan

AU - Liu, Kang

AU - Zheng, Yi

AU - Dai, Zhijun

PY - 2016

Y1 - 2016

N2 - The prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patients with various malignancies. We performed a meta-analysis to determine the predictive potential of PNI in digestive system cancers. Twenty-three studies with a total of 7,384 patients suffering from digestive system carcinomas were involved in this meta-analysis. A lower PNI was significantly associated with the shorter overall survival (OS) [Hazard Ratio (HR) 1.83, 95% Confidence Interval (CI) 1.62-2.07], the poorer disease-free survival (DFS) (HR 1.85, 95% CI 1.19-2.89), and the higher rate of post-operative complications (HR 2.31, 95% CI 1.63-3.28). In conclusion, PNI was allowed to function as an efficient indicator for the prognosis of patients with digestive system carcinomas.

AB - The prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patients with various malignancies. We performed a meta-analysis to determine the predictive potential of PNI in digestive system cancers. Twenty-three studies with a total of 7,384 patients suffering from digestive system carcinomas were involved in this meta-analysis. A lower PNI was significantly associated with the shorter overall survival (OS) [Hazard Ratio (HR) 1.83, 95% Confidence Interval (CI) 1.62-2.07], the poorer disease-free survival (DFS) (HR 1.85, 95% CI 1.19-2.89), and the higher rate of post-operative complications (HR 2.31, 95% CI 1.63-3.28). In conclusion, PNI was allowed to function as an efficient indicator for the prognosis of patients with digestive system carcinomas.

KW - Digestive system carcinomas

KW - Meta-analysis

KW - Prognosis

KW - Prognostic nutritional index

UR - https://www.scopus.com/pages/publications/85007433753

U2 - 10.18632/oncotarget.13472

DO - 10.18632/oncotarget.13472

M3 - 文章

C2 - 27888808

AN - SCOPUS:85007433753

SN - 1949-2553

VL - 7

SP - 86573

EP - 86583

JO - Oncotarget

JF - Oncotarget

IS - 52

ER -

Prognostic nutritional index as a prognostic biomarker for survival in digestive system carcinomas

Abstract

UN SDGs

Keywords

Access to Document

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